Existing datasets for evaluating text-to-image generation focus mostly on real-life images, which poses challenges for assessing academicfigure generation given real scientific captions, which is a hot topic in AI for Science. To fill the gap, we propose HE4AFG, a novel datasetwhich first provides a Holistic Evaluation for Academic caption-to-Figure Generation (AFG). Specifically, HE4AFG collects real figure captions from 8 scientific domains and finally generates 3,900 evaluation samples (particularly, including multi-panel figures) using 5 mainstream large multimodal models (LMMs). For each sample, we provide high-quality human ratings in terms of three aspects—scientific aesthetic (SA), topic relevance (TR), and attribute correctness (AC). Moreover, we present two trainable models: (1) HE4AFG-E, an automated Evaluation model for AFG, which generates aspect-aware training examples and then use them to train three aspect-specific evaluation modules via contrastive learning; (2) HE4AFG-R, an automated Refinement model, which generates and utilizes feedback on the quality of the figures (e.g., unfaithful elements) to continuously improve AFG. Extensive experiments on HE4AFG demonstrate the effectiveness and performance advantages of our models.