Illicit drug use among teenagers and young adults (TYAs) remains a pressing public health concern, with rising prevalence and long-term impacts on health and well-being. To detect illicit drug use among TYAs, researchers analyze large-scale surveys such as the Youth Risk Behavior Survey (YRBS) and the National Survey on Drug Use and Health (NSDUH), which preserve rich demographic, psychological, and environmental factors related to substance use. However, existing modeling methods treat survey variables independently, overlooking latent and interconnected structures among them. To address this limitation, we propose LAMI (LAtent relation Mining with bi-modal Interpretability), a novel joint graph-language modeling framework for detecting illicit drug use and interpreting behavioral risk factors among TYAs. LAMI represents individual responses as relational graphs, learns latent connections through a specialized graph structure learning layer, and integrates a large language model to generate natural language explanations grounded in both graph structures and survey semantics. Experiments on the YRBS and NSDUH datasets show that LAMI outperforms competitive baselines in predictive accuracy. Interpretability analyses further demonstrate that LAMI reveals meaningful behavioral substructures and psychosocial pathways, such as family dynamics, peer influence, and school-related distress, that align with established risk factors for substance use. Our codebase is available here.

Diet plays a central role in human health, and Nutrition Question Answering (QA) offers a promising path toward personalized dietary guidance and the prevention of diet-related chronic diseases. However, existing methods face two fundamental challenges: the limited reasoning capacity of single-agent systems and the complexity of designing effective multi-agent architectures, as well as contextual overload that hinders accurate decision-making. We introduce Nutritional-Graph Router (NG-Router), a novel framework that formulates nutritional QA as a supervised, knowledge-graph–guided multi-agent collaboration problem. NG-Router integrates agent nodes into heterogeneous knowledge graphs and employs a graph neural network to learn task-aware routing distributions over agents, leveraging soft supervision derived from empirical agent performance. To further address contextual overload, we propose a gradient-based subgraph retrieval mechanism that identifies salient evidence during training, thereby enhancing multi-hop and relational reasoning. Extensive experiments across multiple benchmarks and backbone models demonstrate that NG-Router consistently outperforms both single-agent and ensemble baselines, offering a principled approach to domain-aware multi-agent reasoning for complex nutritional health tasks.

Large language models (LLMs) and agent-based frameworks have advanced rapidly, enabling diverse applications. Yet, with the proliferation of models and agentic strategies, practitioners face substantial uncertainty in selecting the best configuration for a downstream task. Prior studies show that different agents and backbones exhibit complementary strengths, and that larger models are not always superior, underscoring the need for adaptive routing mechanisms. Existing approaches to agent routing, however, often emphasize cost efficiency while overlooking the fine-grained contextual and relational structure inherent in QA tasks. In this paper, we propose AgentRouter, a framework that formulates multi-agent QA as a knowledge-graph–guided routing problem supervised by empirical performance signals. Specifically, we convert QA instance into a heterogeneous knowledge graph that jointly encodes queries, contextual entities, and agents, and then train a heterogeneous graph neural network (GNN) to propagate information across node types and produce task-aware routing distributions over agents. By leveraging soft supervision and weighted aggregation of agent outputs, AgentRouter learns principled collaboration schemes that capture the complementary strengths of diverse agents. Extensive experiments demonstrate that our framework consistently outperforms single-agent and ensemble baselines, while generalizing across benchmarks and LLM backbones. These results highlight the effectiveness and robustness of graph-supervised multi-agent routing for question answering. Our code repo is available at https://anonymous.4open.science/r/AgentRouter.