Open-ended tasks, such as coding problems that are common in computer science education, provide detailed insights into student knowledge. However, training large language models (LLMs) to simulate and predict possible student errors in their responses to these problems can be challenging: they often suffer from mode collapse and fail to fully capture the diversity in syntax, style, and solution approach in student responses. In this work, we present KASER (Knowledge-Aligned Student Error Simulator), a novel approach that aligns errors with student knowledge. We propose a training method based on reinforcement learning using a hybrid reward that reflects three aspects of student code prediction: i) code similarity to the ground-truth, ii) error matching, and iii) code prediction diversity. On two real-world datasets, we perform two levels of evaluation and show that: At the per-student-problem pair level, our method outperforms baselines on code and error prediction; at the per-problem level, our method outperforms baselines on error coverage and simulated code diversity.

The advancement in healthcare has shifted focus toward patient-centric approaches, particularly in self-care and patient education, facilitated by access to Electronic Health Records (EHR). However, medical jargon in EHRs poses significant challenges in patient comprehension. To address this, we introduce a new task of automatically generating lay definitions, aiming to simplify complex medical terms into patient-friendly lay language. We first created the README dataset, an extensive collection of over 50,000 unique (medical term, lay definition) pairs and 300,000 mentions, each offering context-aware lay definitions manually annotated by domain experts. We have also engineered a data-centric Human-AI pipeline that synergizes data filtering, augmentation, and selection to improve data quality. We then used README as the training data for models and leveraged a Retrieval-Augmented Generation method to reduce hallucinations and improve the quality of model outputs. Our extensive automatic and human evaluations demonstrate that open-source mobile-friendly models, when fine-tuned with high-quality data, are capable of matching or even surpassing the performance of state-of-the-art closed-source large language models like ChatGPT. This research represents a significant stride in closing the knowledge gap in patient education and advancing patient-centric healthcare solutions.