Large language models (LLMs) have demonstrated strong performance and rapid progress in a wide range of medical reasoning tasks.However, their sequential autoregressive decoding forces inherently parallel clinical reasoning, such as differential diagnosis, into a single linear reasoning path, limiting both efficiency and reliability for complex medical problems.To address this, we propose MedVerse, a reasoning framework for complex medical inference that reformulates medical reasoning as a parallelizable directed acyclic graph (DAG) process based on Petri Net theory.The framework adopts a full-stack design across data, model architecture, and system execution.For data creation, we introduce the MedVerse Curator, an automated pipeline that synthesizes knowledge-grounded medical reasoning path and transforms them into Petri Net–structured representations.At the architectural level, we propose a topology-aware attention mechanism with adaptive position indices that supports parallel reasoning while preserving logical consistency.Systematically, we develop a customized inference engine that supports parallel execution without additional overhead.Empirical evaluations show that MedVerse improves strong general-purpose LLMs by up to 8.9%. Compared to specialized medical LLMs, MedVerse achieves comparable performance with improved clinical reliability, while delivering a 1.3× reduction in inference latency and a 1.7× increase in generation throughput, enabled by its parallel decoding capability.

Clinical trials are pivotal yet costly processes, often spanning multiple years and requiring substantial expenses, motivating predictive models to identify likely-to-fail drugs early and save resources. Recent approaches leverage deep learning to integrate multimodal data for clinical outcome prediction; however, they rely heavily on manually designed modality-specific encoders, limiting their adaptability to new modalities and ability to effectively share information across modalities. To address these challenges, we propose a multimodal mixture-of-experts (LIFTED) framework. Specifically, LIFTED transforms modality-specific data into natural language descriptions, encoded via unified, noise-resilient encoders. A sparse Mixture-of-Experts mechanism then identifies shared patterns across modalities, extracting consistent representations. Finally, another mixture-of-experts module dynamically integrates these modality representations, emphasizing critical information. Experiments show that LIFTED significantly outperforms baseline methods in predicting clinical trial outcomes across all phases, highlighting the effectiveness of our proposed approach.

The recent emergence of Medical Large Vision Language Models (Med-LVLMs) has enhanced medical diagnosis. However, current Med-LVLMs frequently encounter factual issues, often generating responses that do not align with established medical facts. Retrieval-Augmented Generation (RAG), which utilizes external knowledge, can improve the factual accuracy of these models but introduces two major challenges. First, limited retrieved contexts might not cover all necessary information, while excessive retrieval can introduce irrelevant and inaccurate references, interfering with the model’s generation. Second, in cases where the model originally responds correctly, applying RAG can lead to an over-reliance on retrieved contexts, resulting in incorrect answers. To address these issues, we propose RULE, which consists of two components. First, we introduce a provably effective strategy for controlling factuality risk through the calibrated selection of the number of retrieved contexts. Second, based on samples where over-reliance on retrieved contexts led to errors, we curate a preference dataset to fine-tune the model, balancing its dependence on inherent knowledge and retrieved contexts for generation. We demonstrate the effectiveness of RAFE on three medical VQA datasets, achieving an average improvement of 20.8% in factual accuracy.