Large language models (LLMs) have achieved remarkable success across diverse tasks through large-scale pretraining. However, they remain prone to catastrophic forgetting in continual learning. To the best of our knowledge, this is the first work to identify noise accumulation in LoRA updates as a key cause of forgetting in continual learning. A preliminary two-task experiment demonstrates that removing less important components of the second task’s LoRA parameters improves performance on the first task, suggesting that later updates introduce noisy interference. Building on this insight, we propose **S**ubspace-Denoised **Lo**w-**R**ank **A**daptation (**SLoRA**), a simple and effective framework that filters noisy components from LoRA updates via subspace similarity with the base model. SLoRA is a regularization-free method without accessing data or gradients from previous tasks or modifying the training process. It offers two variants, SLoRA-Pre and SLoRA-Post, for online and offline continual learning, respectively. Extensive experiments across tasks and models validate the effectiveness of SLoRA. It improves final accuracy by up to 12%, reduces forgetting by 29%, and filters out over 30% of LoRA parameters identified as noisy. Our code is available at https://github.com/alina1031/SLoRA.

Medical large vision-language Models (Med-LVLMs) have shown promise in clinical applications but suffer from factual inaccuracies and unreliable outputs, posing risks in real-world diagnostics. While RAG has emerged as a potential solution, current medical multimodal RAG systems are unable to perform effective retrieval across heterogeneous sources. The irrelevance of retrieved reports undermines the factuality of analysis, while insufficient knowledge affects the credibility of clinical decision-making. To bridge the research gap, we construct MedAtlas, which includes extensive multimodal report repositories and diverse text corpora. Based on it, we present HeteroRAG, a novel framework that enhances Med-LVLMs through heterogeneous knowledge sources. The framework introduces Modality-specific CLIPs for effective report retrieval and a Multi-corpora Query Generator for tailoring queries to diverse corpora. Incorporating knowledge from such multifaceted sources, Heterogeneous Knowledge Preference Tuning is performed to achieve cross-modality and multi-source knowledge alignment. Extensive experiments across 11 datasets and 3 modalities demonstrate that HeteroRAG achieves state-of-the-art performance in most medical vision language benchmarks, significantly improving factual accuracy and reliability of Med-LVLMs.

Omni Large Language Models (Omni-LLMs) have demonstrated impressive capabilities in holistic multi-modal perception, yet they consistently falter in complex scenarios requiring synergistic omni-modal reasoning. Beyond understanding global multimodal context, effective reasoning also hinges on fine-grained cross-modal alignment, especially identifying shared referents across modalities, yet this aspect has been largely overlooked. To bridge this gap, we formalize the challenge as a cross-modal coreference problem, where a model must localize a referent in a source modality and re-identify it in a target modality. Building on this paradigm, we introduce CrossOmni, a dataset comprising nine tasks equipped with human-designed reasoning rationales to evaluate and enhance this capability. Experiments on 13 Omni-LLMs reveal systematic weaknesses in cross-modal coreference, which we attribute to the absence of coreference-aware thinking patterns. To address this, we enhance cross-modal alignment via two strategies: a training-free In-Context Learning method and a training-based SFT+GRPO framework designed to induce such thinking patterns. Both approaches yield substantial performance gains and generalize effectively to collaborative reasoning tasks. Overall, our findings highlight cross-modal coreference as a crucial missing piece for advancing robust omni-modal reasoning.

Current critic-free RL methods for large reasoning models suffer from severe inefficiency when training on positive homogeneous prompts (where all rollouts are correct), resulting in waste of rollouts due to zero advantage estimates. We introduce a radically simple yet powerful solution to Mine intrinsic mastery (Miner), that repurposes the policy’s intrinsic uncertainty as a self-supervised reward signal, with no external supervision, auxiliary models, or additional inference cost. Our method pioneers two key innovations: (1) a token-level focal credit assignment mechanism that dynamically amplifies gradients on critical uncertain tokens while suppressing overconfident ones, and (2) adaptive advantage calibration to seamlessly integrate intrinsic and verifiable rewards. Evaluated across six reasoning benchmarks on Qwen3-4B and Qwen3-8B base models, Miner achieves state-of-the-art performance among the other four algorithms, yielding up to 4.58 absolute gains in Pass@1 and 6.66 gains in Pass@K compared to GRPO. Comparison with other methods targeted at exploration enhancement further discloses the superiority of the two newly proposed innovations. This demonstrates that latent uncertainty exploitation is both necessary and sufficient for efficient and scalable RL training of reasoning models. Code is available at https://github.com/pixas/Miner.

Multimodal large language models (MLLMs) have shown strong capabilities across a broad range of benchmarks. However, most existing evaluations focus on passive inference, where models perform step-by-step reasoning under complete information. This setup is misaligned with real-world use, where seeing is not enough. This raises a fundamental question: Can MLLMs actively acquire missing evidence under incomplete information? To bridge this gap, we require the MLLMs to actively acquire missing evidence and iteratively refine decisions under incomplete information, by selecting a target image from a candidate pool without task-specific priors. To support systematic study, we propose GuessBench, a benchmark with both perception-oriented and knowledge-oriented images for evaluating active reasoning in MLLMs. We evaluate 20 superior MLLMs and find that performance on active reasoning lags far behind it on passive settings, indicating substantial room for improvement. Further analysis identifies fine-grained perception and timely decision-making as key challenges. Ablation studies show that perceptual enhancements benefit smaller models, whereas thinking-oriented methods provide consistent gains across model sizes. These results suggest promising directions for future research on multimodal active reasoning.

Large Language Models (LLMs) have shown promising potential in the medical domain, assisting with tasks like clinical note generation and patient communication. However, current LLMs are limited to text-based communication, hindering their ability to interact with diverse forms of information in clinical environments. Despite clinical agents succeeding in diverse signal interaction, they are oriented to a single clinical scenario and hence fail for broader applications. To evaluate clinical agents holistically, we propose ClinicalAgent Bench (CAB), a comprehensive medical agent benchmark consisting of 18 tasks across five key realistic clinical dimensions. Building on this, we introduce ReflectTool, a novel framework that excels at utilizing domain-specific tools within two stages. The first optimization stage progressively enlarges a long-term memory by saving successful solving processes and tool-wise experience of agents in a tiny pre-defined training set. In the following inference stage, ReflectTool can search for supportive successful demonstrations from already built long-term memory to guide the tool selection strategy, and a verifier improves the tool usage according to the tool-wise experience with two verification methods–iterative refinement and candidate selection. Extensive experiments on CAB demonstrate that ReflectTool surpasses the pure LLMs with more than 10 points and the well-established agent-based methods with 3 points, highlighting its adaptability and effectiveness in solving complex clinical tasks. Our code and datasets are available at https://github.com/BlueZeros/ReflecTool.

Large language models hold promise for addressing medical challenges, such as medical diagnosis reasoning, research knowledge acquisition, clinical decision-making, and consumer health inquiry support. However, they often generate hallucinations due to limited medical knowledge. Incorporating external knowledge is therefore critical, which necessitates multi-source knowledge acquisition. We address this challenge by framing it as a source planning problem, which is to formulate context-appropriate queries tailored to the attributes of diverse sources. Existing approaches either overlook source planning or fail to achieve it effectively due to misalignment between the model’s expectation of the sources and their actual content. To bridge this gap, we present MedOmniKB, a repository comprising multigenre and multi-structured medical knowledge sources. Leveraging these sources, we propose the Source Planning Optimisation method, which enhances multi-source utilisation. Our approach involves enabling an expert model to explore and evaluate potential plans while training a smaller model to learn source alignment. Experimental results demonstrate that our method substantially improves multi-source planning performance, enabling the optimised small model to achieve state-of-the-art results in leveraging diverse medical knowledge sources.

When performing reasoning tasks with user-specific requirements, such as strict output formats, large language models (LLMs) often prioritize reasoning over adherence to detailed instructions. Fine-tuning LLMs on supervised datasets to address this is impractical due to high computational costs and limited parameter access. To tackle this, we propose DICE, a lightweight framework that guides small language models (SLMs) to refine LLMs’ outputs through chain-of-thought (CoT) correction. DICE decouples the process by first prompting LLMs to generate natural language responses, then using trained SLMs to analyze and refine these outputs to meet structured output specifications. This framework preserves LLMs’ broad knowledge and reasoning capabilities while ensuring the outputs conform to user demands. Specifically, DICE first constructs structured CoT adaptation datasets via a two-stage method and subsequently applies a dual-tuning strategy to fine-tune SLMs for generating structured outputs in an analyze-then-answer pattern. Experiments demonstrate that DICE improves the average format accuracy and content correctness of LLM outputs by 35.4% and 29.4%, respectively, achieving state-of-the-art (SOTA) performance over other competitive baselines.

The reliability of large language models remains a critical challenge, particularly due to their susceptibility to hallucinations and factual inaccuracies during text generation. Existing solutions either underutilize models’ self-correction with preemptive strategies or use costly post-hoc verification. To further explore the potential of real-time self-verification and correction, we present Dynamic Self-Verify Decoding (DSVD), a novel decoding framework that enhances generation reliability through real-time hallucination detection and efficient error correction. DSVD integrates two key components: (1) parallel self-verification architecture for continuous quality assessment, (2) dynamic rollback mechanism for targeted error recovery. Extensive experiments across five benchmarks demonstrate DSVD’s effectiveness, achieving significant improvement in truthfulness (Quesetion-Answering) and factual accuracy (FActScore). Results show the DSVD can be further incorporated with existing faithful decoding methods to achieve stronger performance. Our work establishes that real-time self-verification during generation offers a viable path toward more trustworthy language models without sacrificing practical deployability.

While chains-of-thought (CoT) have advanced complex reasoning in multimodal large language models (MLLMs), existing methods remain confined to text or static visual domains, often faltering in dynamic spatial reasoning tasks. To bridge this gap, we present GRASSLAND, a novel maze navigation benchmark designed to evaluate dynamic spatial reasoning. Our experiments show that augmenting textual reasoning chains with dynamic visual drafts, overlaid on input images, significantly outperforms conventional approaches, offering new insights into spatial reasoning in evolving environments. To generalize this capability, we propose D2R (Dynamic Draft-Augmented Reasoning), a training-free framework that seamlessly integrates textual CoT with corresponding visual drafts into MLLMs. Extensive evaluations demonstrate that D2R consistently enhances performance across diverse tasks, establishing a robust baseline for dynamic spatial reasoning without requiring model fine-tuning.

Large language models (LLMs) are trained on extensive historical corpora, but their ability to understand time and maintain temporal awareness of time-evolving factual knowledge remains limited. Previous studies often neglect the critical aspect of utilizing knowledge from various sources. To address this gap, we introduce EvolveBench, a comprehensive benchmark that evaluates temporal competence along five key dimensions: Cognition, which examines the ability to recall and contextualize historical facts. Awareness, which tests LLMs’ awareness of temporal misalignment between external inputs and the temporal context of a query. Trustworthiness, which assesses whether models can identify and appropriately refuse queries based on invalid timestamps. Understanding, which focuses on interpreting both explicit dates and implicit historical markers. Finally, reasoning evaluates the capacity to analyze temporal relationships and draw accurate inferences. Evaluating 15 widely used LLMs on EvolveBench shows that GPT-4o achieves the highest average EM score of 79.36, while the open-source Llama3.1-70B demonstrates notable strength in handling temporally misaligned contexts with an average score of 72.47. Despite these advances, all models still struggle with handling temporal misaligned context. Our code and dataset are available at https://github.com/zzysjtuiwct/EvolveBench.

Speech large language models (LLMs) have emerged as a prominent research focus in speech processing. In this work, we introduce VocalNet, a series of high-performance speech LLMs featuring a scalable and model-agnostic training framework as well as a novel multi-token prediction (MTP) paradigm for speech generation. We first propose an efficient two-stage training framework that enables LLMs to acquire real-time speech interaction capabilities. Through extensive experiments on various training configurations, we ensure both simplicity and effectiveness in the training strategy. Furthermore, inspired by advances in language modeling, we introduce MTP into the domain of speech LLMs—an alternative to traditional next-token prediction (NTP)—which enables the model to predict multiple future tokens at each step. Through systematic analysis and improved implementation, we show that MTP not only accelerates inference speed but also significantly enhances speech quality. Experimental results demonstrate that VocalNet achieves performance comparable to state-of-the-art Omni LLMs while outperforming existing open-source speech LLMs, despite using limited training data.

Generating faithful and fast responses is crucial in the knowledge-grounded dialogue. Retrieval Augmented Generation (RAG) strategies are effective but are inference inefficient, while previous Retrieval Free Generations (RFG) are more efficient but sacrifice faithfulness. To solve this faithfulness-efficiency trade-off dilemma, we propose a novel retrieval-free model training scheme named Retrieval Augmented to Retrieval Free Distillation (RA2FD) to build a retrieval-free model that achieves higher faithfulness than the previous RFG method while maintaining inference efficiency. The core idea of RA2FD is to use a teacher-student framework to distill the faithfulness capacity of a teacher, which is an oracle RAG model that generates multiple knowledge-infused responses. The student retrieval-free model learns how to generate faithful responses from these teacher labels through sequence-level distillation and contrastive learning. Experiment results show that RA2FD let the faithfulness performance of an RFG model surpass the previous SOTA RFG baseline on three knowledge-grounded dialogue datasets by an average of 33% and even matching an RAG model’s performance while significantly improving inference efficiency. Our code is available at https://github.com/zzysjtuiwct/RA2FD.

Large language models (LLMs) have shown substantial progress in natural language understanding and generation, proving valuable especially in the medical field. Despite advancements, challenges persist due to the complexity and diversity inherent in medical tasks, which can be categorized as knowledge-intensive tasks and alignment-required tasks. Previous approaches either ignore the latter task or focus on a minority of tasks and hence lose generalization. To address these drawbacks, we propose a progressive fine-tuning pipeline. This pipeline employs a and a to encode diverse knowledge in the first stage and filter out detrimental information. In the second stage, we drop the to avoid the interference of suboptimal representation and leverage an additional alignment module optimized towards an orthogonal direction to the knowledge space to mitigate knowledge forgetting. Based on this two-stage paradigm, we proposed a Medical LLM through decoupling Clinical Alignment and Knowledge Aggregation (), which is designed to achieve promising performance on over 20 medical tasks, as well as results on specific medical alignment tasks. Various model sizes of (1.8B, 7B, 14B) all demonstrate significant improvements over existing models with similar model sizes. Our code and datasets are available at https://github.com/BlueZeros/MedCare.

Structured data offers an efficient means of organizing information. Exsisting text-serialization based methods for processing structured data using large language models (LLMs) are not designed to explicitly capture the heterogeneity of structured data. Such methods are suboptimal for LLMs to process structured data, and may lead to large input token size and poor robustness to input perturbation. In this paper, we propose a novel framework called DictLLM, which is an efficient and effective framework for the modeling of medical lab report to deal with the report-assisted diagnosis generation task. DictLLM introduce 1) group positional encoding to maintain the permutation invariance, 2) hierarchical attention bias to capture the inductive bias of structured data, and 3) a optimal transport alignment layer to align the embeddings generated by the dict encoder with the LLM, producing a list of fixed-length virtual tokens. We conduct experiments with multiple LLM models on a large-scale real-world medical lab report dataset for automatic diagnosis generation. The results show that our proposed framework outperforms the baseline methods and few-shot GPT-4 in terms of both Rouge-L and Knowledge F1 score. We also conduct multiple experiments and analyze the scalability and robustness of our proposed framework, demonstrating the superiority of our method in modeling the heterogeneous structure of medical dictionaries data.

In the realm of text-conditioned image retrieval, models utilize a query composed of a reference image and modification text to retrieve corresponding images. Despite its significance, this task is fraught with challenges, including small-scale datasets due to labeling costs and the complexity of attributes in modification texts. These challenges often result in models learning a generalized representation of the query, thereby missing the semantic correlations of image and text attributes.In this paper, we introduce a general boosting framework designed to address these issues by employing semantic discrepancy alignment. Our framework first leverages the ChatGPT to augment text data by modifying the original modification text’s attributes. The augmented text is then combined with the original reference image to create an augmented composed query. Then we generate corresponding images using GPT-4 for the augmented composed query.We realize the cross-modal semantic discrepancy alignment by formulating distance consistency and neighbor consistency between the image and text domains. Through this novel approach, attribute in the text domain can be more effectively transferred to the image domain, enhancing retrieval performance. Extensive experiments on three prominent datasets validate the effectiveness of our approach, with state-of-the-art results on a majority of evaluation metrics compared to various baseline methods.

In text-conditioned image retrieval (TCIR), the combination of a reference image and modification text forms a query tuple, aiming to locate the most congruent target image within a dataset. The advantages of rich image semantic information and text flexibility are combined in this manner for more accurate retrieval. While traditional techniques often employ attention-driven compositors to craft a unified image-text representation, our paper introduces a compositor-free framework, CF-TCIR, which eschews the standard compositor. Compositor-based methods are designed to learn a joint representation of images and text, but they struggle to directly capture the correlations between attributes across the image and text modalities. Instead, we reformulate the retrieval process as a cross-modal interaction between a synthesized image feature and its corresponding text descriptor. This novel methodology offers advantages in terms of computational efficiency, scalability, and superior performance. To optimize the retrieval performance, we advocate a tiered retrieval mechanism, blending both coarse-grain and fine-grain paradigms. Moreover, to enrich the contextual relationship within the query tuple, we integrate a generative cross-modal alignment technique, ensuring synchronization of sequential attributes between image and text data.

Heart sound auscultation holds significant importance in the diagnosis of congenital heart disease. However, existing methods for Heart Sound Diagnosis (HSD) tasks are predominantly limited to a few fixed categories, framing the HSD task as a rigid classification problem that does not fully align with medical practice and offers only limited information to physicians. Besides, such methods do not utilize echocardiography reports, the gold standard in the diagnosis of related diseases. To tackle this challenge, we introduce HSDreport, a new benchmark for HSD, which mandates the direct utilization of heart sounds obtained from auscultation to predict echocardiography reports. This benchmark aims to merge the convenience of auscultation with the comprehensive nature of echocardiography reports. First, we collect a new dataset for this benchmark, comprising 2,275 heart sound samples along with their corresponding reports. Subsequently, we develop a knowledge-aware query-based transformer to handle this task. The intent is to leverage the capabilities of medically pre-trained models and the internal knowledge of large language models (LLMs) to address the task’s inherent complexity and variability, thereby enhancing the robustness and scientific validity of the method. Furthermore, our experimental results indicate that our method significantly outperforms traditional HSD approaches and existing multimodal LLMs in detecting key abnormalities in heart sounds.