Neural Processing Units (NPUs) are critical for AI infrastructure, yet developing kernels remains a bottleneck due to the complexity of vendor-specific Domain-Specific Languages (DSLs). While LLMs excel in general coding, they fail to meet the stringent constraints of NPU development, showing a near-zero success rate on complex kernels in our preliminary study. To address these challenges, we present AscendKernelGen, the first comprehensive framework for NPU kernel development, marking a pioneering effort in this field. This framework consists of three interconnected components: (1) Ascend-CoT, the first dataset in the NPU kernel domain that incorporates chain-of-thought reasoning from real-world kernel implementations; (2) KernelGen-LM, a domain-adaptive model trained on this novel dataset using supervised fine-tuning and reinforcement learning; and (3) NPUKernelBench, the first benchmark platform designed to evaluate the compilation, correctness, and performance of generated NPU kernels. Experimental results demonstrate that our approach dramatically bridges the gap in hardware-specific coding: compilation success on complex Level-2 kernels improves from 0% to 95.5% (Pass@10), with 64% functional correctness. AscendKernGen is available at AscendKernGen and NPUKernelBench.

Large language models (LLMs) have demonstrated significant reasoning capabilities in scientific discovery but struggle to bridge the gap to physical execution in wet-labs. In these irreversible environments, probabilistic hallucinations are not merely incorrect; they can cause equipment damage or experimental failure. To address this, we propose BioProAgent, a neuro-symbolic framework that anchors probabilistic planning in a deterministic Finite State Machine (FSM). We introduce a State-Augmented Planning mechanism that enforces a rigorous Design-Verify-Rectify workflow, ensuring hardware compliance before execution. Furthermore, we address the context bottleneck inherent in complex device schemas by Semantic Symbol Grounding, reducing token consumption by ∼6× through symbolic abstraction. In the extended BioProBench benchmark, BioProAgent achieves 95.6% physical compliance (compared to 21.0% for ReAct), demonstrating that neuro-symbolic constraints are essential for reliable autonomy in irreversible physical environments. Code at https://github.com/YuyangSunshine/bioproagent and Website at https://yuyangsunshine.github.io/BioPro-Project/ .

Cross-domain sequential recommendation (CSR) has garnered significant attention. Current federated frameworks for CSR leverage information across multiple domains but often rely on user alignment, which increases communication costs and privacy risks. In this work, we propose FedCSR, a novel federated cross-domain sequential recommendation framework that eliminates the need for user alignment between platforms. FedCSR fully utilizes cross-domain knowledge to address the key challenges related to data heterogeneity both inter- and intra-platform. To tackle the heterogeneity of data patterns between platforms, we introduce Model Contrastive Learning (MCL) to reduce the gap between local and global models. Additionally, we design Sequence Contrastive Learning (SCL) to address the heterogeneity of user preferences across different domains within a platform by employing tailored sequence augmentation techniques. Extensive experiments conducted on multiple real-world datasets demonstrate that FedCSR achieves superior performance compared to existing baseline methods.

Large Language Models (LLMs) have demonstrated powerful performance in sequential recommendation due to their robust language modeling and comprehension capabilities. In such paradigms, the item texts of interaction sequences are formulated as sentences and LLMs are utilized to learn language representations or directly generate target item texts by incorporating instructions. Despite their promise, these methods solely focus on modeling the mapping from sequential texts to target items, neglecting the relationship between the items in an interaction sequence. This results in a failure to learn the transition patterns between items, which reflect the dynamic change in user preferences and are crucial for predicting the next item. To tackle this issue, we propose a novel framework for mapping the sequential item texts to the sequential item IDs, named ST2SI. Specifically, we first introduce multi-query input and item linear projection (ILP) to model the conditional probability distribution of items. Then, we further propose ID alignment to address misalignment between item texts and item IDs by instruction tuning. Finally, we propose efficient ILP tuning to adapt flexibly to different scenarios, requiring only training a linear layer to achieve competitive performance. Extensive experiments on six real-world datasets show our approach outperforms the best baselines by 7.33% in NDCG@10, 4.65% in Recall@10, and 8.42% in MRR.