Interactive medical questioning is essential in clinical consultations, where physicians must actively gather necessary patient information. Yet existing medical Large Language Models (LLMs) predominantly follow a reactive paradigm, risking diagnostic errors by answering before seeking sufficient details. To bridge this gap, we propose ProMed, a reinforcement learning framework that transitions LLMs toward a proactive paradigm, enabling them to ask clinically valuable questions before decision-making. Central to ProMed is the Shapley Information Gain (SIG) reward, which quantifies a question’s clinical utility as the amount of newly acquired information, while considering its contextual importance via Shapley values. We integrate SIG into a two-stage training pipeline: (1) SIG-Guided Model Initialization uses Monte Carlo Tree Search to construct high-reward interaction trajectories for supervision, and (2) SIG-Augmented Policy Optimization, with a novel SIG-guided Reward Distribution Mechanism that prioritizes informative questions for fine-grained optimization. Experiments on partial-information medical benchmarks show that ProMed significantly outperforms state-of-the-art methods by 6.29% on average and delivers a 54.45% gain over the reactive paradigm, and generalizes robustly to out-of-domain cases. Our codes are available at https://github.com/hxxding/ProMed.

Continual learning (CL) for large language models (LLMs) aims to enable sequential knowledge acquisition without catastrophic forgetting. Memory replay methods are widely used for their practicality and effectiveness, but most rely on fixed, step-based heuristics that often misalign with the model’s actual learning progress, since identical training steps can result in varying degrees of parameter change. Motivated by recent findings that LLM forgetting mirrors the Ebbinghaus human forgetting curve, we propose FOREVER (FORgEtting curVe-inspired mEmory Replay), a novel CL framework that aligns replay schedules with a model-centric notion of time. FOREVER defines model time using the magnitude of optimizer updates, allowing forgetting curve-inspired replay intervals to align with the model’s internal evolution rather than raw training steps. Building on this approach, FOREVER incorporates a forgetting curve-based replay scheduler to determine when to replay and an intensity-aware regularization mechanism to adaptively control how to replay. Extensive experiments on three CL benchmarks and models ranging from 0.6B to 13B parameters demonstrate that FOREVER consistently mitigates catastrophic forgetting.

Federated Retrieval (FR) routes queries across multiple external knowledge sources, to mitigate hallucinations of LLMs, when necessary external knowledge is distributed. However, existing methods struggle to retrieve high-quality and relevant documents for ambiguous queries, especially in cross-domain scenarios, which significantly limits their effectiveness in supporting downstream generation tasks. Inspired by Dynamic Information Flow (DIF), we propose DFAMS, a novel framework that leverages DIF to identify latent query intents and construct semantically aligned knowledge partitions for accurate retrieval across heterogeneous sources. Specifically, DFAMS probes the DIF in LLMs by leveraging gradient signals from a few annotated queries and employing Shapley value-based attribution to trace neuron activation paths associated with intent recognition and subdomain boundary detection. Then, DFAMS leverages DIF to train an alignment module via multi-prototype contrastive learning, enabling fine-grained intra-source modeling and inter-source semantic alignment across knowledge bases. Experimental results across five benchmarks show that DFAMS outperforms advanced FR methods by up to 14.37% in knowledge classification accuracy, 5.38% in retrieval recall, and 6.45% in downstream QA accuracy, demonstrating its effectiveness in complex FR scenarios. Our code is publicly available at https://github.com/Artessay/DFAMS.

Large Language Models (LLMs) excel in general language tasks, motivating their adaptation to specialized domains such as healthcare. Effective domain adaptation typically involves supervised fine-tuning (SFT) on carefully selected instruction-tuning data. Current data selection methods adopt a data-centric approach, relying on external annotations and heuristics to identify externally defined high-quality or challenging data. Our exploratory experiments highlight this approach fails to improve the model’s domain performance, due to misalignment between selected data and the model’s knowledge distribution. To tackle this, we propose Decomposed Difficulty-based Data Selection (3DS), a two-stage model-centric data selection framework that aligns data selection with the model’s distribution. 3DS employs Prompt-Driven Data Selection to filter out noise based on the model’s knowledge via explicit alignment in Stage#1, then adopts Decomposed Difficulty-based Data Selection to guide selection via three novel data difficulty metrics, including Instruction Understanding, Response Confidence, and Response Correctness in Stage#2, enhanced by an attention-based importance weighting mechanism for accurate calibration.Extensive experiments in the healthcare domain show 3DS outperforms existing methods by up to 2.97% accuracy, with additional validation in law and general domains, confirming its generalization ability. Our dataset and code are open-sourced at https://github.com/PuppyKnightUniversity/3DS.

Continual learning (CL) is essential for deploying large language models (LLMs) in dynamic real-world environments without the need for costly retraining. Recent model merging-based methods have attracted significant attention, but they still struggle to effectively manage the trade-off between learning new knowledge and preventing forgetting, a challenge largely stemming from suboptimal number of merges and merging frequency. In this paper, we introduce Adaptive Iterative Model Merging (AimMerging), a novel CL framework that utilizes learning and forgetting signals from the training trajectory to dynamically monitor the model’s training status. Guided by dynamic monitoring, the training trajectory-guided merge controller adaptively determines the timing and frequency of iterative fusion, while the rehearsal-based knowledge fusion module computes the merging weights and executes the fusion. Comprehensive experiments on three CL benchmarks with various model sizes (from 770M to 13B) demonstrate that AimMerging achieves significant performance improvements over existing state-of-the-art methods, with an average relative improvement of 80% and 59% on FWT and BWT, respectively. The source code is provided for reproducibility.

Regular updates are essential for maintaining up-to-date knowledge in large language models (LLMs). However, existing training-based model editing methods often struggle to effectively incorporate new knowledge while preserving unrelated general knowledge. To address this challenge, we propose a novel framework called Geometric Knowledge Editing (GeoEdit). GeoEdit utilizes the geometric relationships of parameter updates from fine-tuning to differentiate between neurons associated with new knowledge updates and those related to general knowledge perturbations. By employing a direction-aware knowledge identification method, we avoid updating neurons with directions approximately orthogonal to existing knowledge, thus preserving the model’s generalization ability. For the remaining neurons, we integrate both old and new knowledge for aligned directions and apply a “forget-then-learn” editing strategy for opposite directions. Additionally, we introduce an importance-guided task vector fusion technique that filters out redundant information and provides adaptive neuron-level weighting, further enhancing model editing performance. Extensive experiments on two publicly available datasets demonstrate the superiority of GeoEdit over existing state-of-the-art methods.

In this paper, we investigate the retrieval-augmented generation (RAG) based on Knowledge Graphs (KGs) to improve the accuracy and reliability of Large Language Models (LLMs). Recent approaches suffer from insufficient and repetitive knowledge retrieval, tedious and time-consuming query parsing, and monotonous knowledge utilization. To this end, we develop a Hypothesis Knowledge Graph Enhanced (HyKGE) framework, which leverages LLMs’ powerful reasoning capacity to compensate for the incompleteness of user queries, optimizes the interaction process with LLMs, and provides diverse retrieved knowledge. Specifically, HyKGE explores the zero-shot capability and the rich knowledge of LLMs with Hypothesis Outputs to extend feasible exploration directions in the KGs, as well as the carefully curated prompt to enhance the density and efficiency of LLMs’ responses. Furthermore, we introduce the HO Fragment Granularity-aware Rerank Module to filter out noise while ensuring the balance between diversity and relevance in retrieved knowledge. Experiments on two Chinese medical multiple-choice question datasets and one Chinese open-domain medical Q&A dataset with two LLM turbos demonstrate the superiority of HyKGE in terms of accuracy and explainability. Code is available at https://github.com/Artessay/HyKGE.

Retrieval-Augmented Generation (RAG) offers an effective solution to the issues faced by Large Language Models (LLMs) in hallucination generation and knowledge obsolescence by incorporating externally retrieved knowledge. However, existing methods lack effective control mechanisms for integrating internal and external knowledge. Inspired by human cognitive processes, we propose Parenting, a novel framework that decouples, identifies, and purposefully optimizes parameter subspaces related to adherence and robustness. Specifically, Parenting utilizes a key parameter mining method that combines forward and backward propagation signals to localize subspaces representing different capabilities. Then, Parenting employs a type-tailored tuning strategy, applying specific and appropriate optimizations to different subspaces, aiming to achieve a balanced enhancement of both adherence and robustness. Extensive experiments on various datasets and models validate the effectiveness and generalizability of our method. Our code is available at https://github.com/Nostradamus4869/Parenting.

In the pursuit of enhancing domain-specific Large Language Models (LLMs), Retrieval-Augmented Generation (RAG) emerges as a promising solution to mitigate issues such as hallucinations, outdated knowledge, and limited expertise in highly specialized queries. However, existing approaches to RAG fall short by neglecting system state variables, which are crucial for ensuring adaptive control, retrieval halting, and system convergence. In this paper, we introduce the Turing-Complete-RAG (TC-RAG) through rigorous proof, a novel framework that addresses these challenges by incorporating a Turing Complete System to manage state variables, thereby enabling more efficient and accurate knowledge retrieval. By leveraging a memory stack system with adaptive retrieval, reasoning, and planning capabilities, TC-RAG not only ensures the controlled halting of retrieval processes but also mitigates the accumulation of erroneous knowledge via Push and Pop actions. In the case study of the medical and general domain, our extensive experiments on seven real-world healthcare and general-domain datasets demonstrate the superiority of TC-RAG over existing methods in accuracy by over 7.20%. Our code, datasets and RAG resources have been available at https://github.com/Artessay/TC-RAG.

Continual learning (CL) is crucial for deploying large language models (LLMs) in dynamic real-world environments without costly retraining. While recent model ensemble and model merging methods guided by parameter importance have gained popularity, they often struggle to balance knowledge transfer and forgetting, mainly due to the reliance on static importance estimates during sequential training. In this paper, we present Recurrent-KIF, a novel CL framework for Recurrent Knowledge Identification and Fusion, which enables dynamic estimation of parameter importance distributions to enhance knowledge transfer. Inspired by human continual learning, Recurrent-KIF employs an inner loop that rapidly adapts to new tasks while identifying important parameters, coupled with an outer loop that globally manages the fusion of new and historical knowledge through redundant knowledge pruning and key knowledge merging. These inner-outer loops iteratively perform multiple rounds of fusion, allowing Recurrent-KIF to leverage intermediate training information and adaptively adjust fusion strategies based on evolving importance distributions. Extensive experiments on two CL benchmarks with various model sizes (from 770M to 13B) demonstrate that Recurrent-KIF effectively mitigates catastrophic forgetting and enhances knowledge transfer.

Extracting semantic topics from short texts presents a significant challenge in the field of data mining. While efforts have been made to mitigate data sparsity issue, the limited length of short documents also results in the absence of semantically relevant words, causing biased evidence lower bound and incomplete labels for likelihood maximization. We refer to this issue as the label sparsity problem. To combat this problem, we propose kNNTM, a neural short text topic model that incorporates a k-Nearest-Neighbor-based label completion algorithm by augmenting the reconstruction label with k-nearest documents to complement these relevant but unobserved words. Furthermore, seeking a precise reflection of distances between documents, we propose a fused multi-view distances metric that takes both local word similarities and global topic semantics into consideration. Extensive experiments on multiple public short-text datasets show that kNNTM model outperforms the state-of-the-art baseline models and can derive both high-quality topics and document representations.

Extracting structured knowledge from unstructured text data has a wide range of application prospects, and a pervasive trend is to develop text annotation tools to help extraction. However, they often encounter issues such as single scenario usage, lack of effective human-machine collaboration, insufficient model supervision, and suboptimal utilization of Large Language Models (LLMs). We introduces an interactive unstructured text annotation and knowledge extraction system that synergistically integrates LLMs and ModelOps to alleviate these issues. The system leverages LLMs for enhanced performance in low-resource contexts, employs a ModelOps platform to monitor models throughout their lifecycle, and amalgamates interactive annotation methods with online machine learning and active learning. The demo video and website are now publicly available.

Efforts have been made to apply topic seed words to improve the topic interpretability of topic models. However, due to the semantic diversity of natural language, supervisions from seed words could be ambiguous, making it hard to be incorporated into the current neural topic models. In this paper, we propose SeededNTM, a neural topic model enhanced with supervisions from seed words on both word and document levels. We introduce a context-dependency assumption to alleviate the ambiguities with context document information, and an auto-adaptation mechanism to automatically balance between multi-level information. Moreover, an intra-sample consistency regularizer is proposed to deal with noisy supervisions via encouraging perturbation and semantic consistency. Extensive experiments on multiple datasets show that SeededNTM can derive semantically meaningful topics and outperforms the state-of-the-art seeded topic models in terms of topic quality and classification accuracy.