Empathetic speech dialogue requires not only understanding linguistic content but also perceiving rich paralinguistic information such as prosody, tone, and emotional intensity for affective understandings. Existing speech-to-speech large language models either rely on ASR transcription or use encoders to extract latent representations, often weakening affective information and contextual coherence in multi-turn dialogues. To address this, we propose ES4R, a framework for speech-based empathetic response generation. Our core innovation lies in explicitly modeling structured affective context before speech encoding, rather than relying on implicit learning by the encoder or explicit emotion supervision. Specifically, we introduce a dual-level attention mechanism to capture turn-level affective states and dialogue-level affective dynamics. The resulting affective representations are then integrated with textual semantics through speech-guided cross-modal attention to generate empathetic responses. For speech output, we employ energy-based strategy selection and style fusion to achieve empathetic speech synthesis. ES4R consistently outperforms strong baselines in both automatic and human evaluations and remains robust across different Large Language Model (LLM) backbones. Code: https://github.com/Bean0901/ES4R.

Efficiently aligning visual features with Large Language Models (LLMs) remains a critical bottleneck in Multimodal LLMs. Existing query-based alignment modules (e.g., Q-Former) rely on randomly initialized queries, resulting in an inefficient cold start exploration process. Furthermore, they enforce uniform cross-attention across all layers, leading to computational redundancy. Our empirical analysis reveals that query tokens initialized with language priors can rapidly capture global semantics, leading to early representation convergence after only a few layers. In this paper, we propose **Cat-MoD**, a **Ca**ption **t**oken Guided Asymmetric **M**ixture-**o**f-**D**epths framework. It incorporates a **Hybrid Query Construction** module where Guide Tokens initialized from coarse-grained linguistic priors rapidly anchor global semantic context, and randomly initialized Explorer Tokens remain active to capture fine-grained visual details. Exploiting this early convergence, we introduce an **Asymmetric Mixture-of-Depths** mechanism, where a similarity-aware router dynamically prunes redundant tokens from expensive cross-attention layers while preserving their context in self-attention. Experiments on multiple benchmarks demonstrate that Cat-MoD matches or surpasses baseline performance, while substantially reducing alignment FLOPs by approximately 37% during both training and inference, offering a highly efficient solution for multimodal alignment. Code: https://github.com/JasonOrange0726/Cat-MoD.