Biomedical document-level relation extraction poses significant challenges beyond sentence-level tasks, as it necessitates the integration of evidence from entire documents and the ability for coherent cross-sentence reasoning. While pretrained language models (PLMs) demonstrate efficiency in handling local contexts, they often struggle with global dependency modeling. Conversely, large language models (LLMs) exhibit strong reasoning capabilities but tend to generate hallucinations in knowledge-intensive biomedical domains. This paper introduces CoRE, a novel cascade framework that leverages the complementary strengths of PLMs and LLMs through a detect-then-rethink paradigm. The PLM serves as an efficient detector for high-confidence relations, while challenging cases are forwarded to an LLM enhanced with semantic retrieval and iterative reasoning mechanisms. Experimental results on BioRED and CDR datasets show that CoRE achieves substantial improvements over state-of-the-art baselines, validating the effectiveness of the proposed cascade paradigm for complex biomedical relation extraction.

Multilingual biomedical entity linking (MBEL) aims to map language-specific mentions in the biomedical text to standardized concepts in a multilingual knowledge base (KB) such as Unified Medical Language System (UMLS). In this paper, we propose Con2GEN, a prompt-based controllable contrastive generation framework for MBEL, which summarizes multidimensional information of the UMLS concept mentioned in biomedical text into a natural sentence following a predefined template. Instead of tackling the MBEL problem with a discriminative classifier, we formulate it as a sequence-to-sequence generation task, which better exploits the shared dependencies between source mentions and target entities. Moreover, Con2GEN matches against UMLS concepts in as many languages and types as possible, hence facilitating cross-information disambiguation. Extensive experiments show that our model achieves promising performance improvements compared with several state-of-the-art techniques on the XL-BEL and the Mantra GSC datasets spanning 12 typologically diverse languages.