Recent advances in Large Vision–language Models (VLMs) suggest their potential for multimodal misinformation detection. However, existing multimodal misinformation detectors often fail to effectively integrate them, relying instead on passive aggregation of multimodal features and social signals. Such correlation-driven paradigms are vulnerable to spurious associations and multimodal noise, and lack explicit verification mechanisms. In this paper, we propose Logic-Guided Adaptive Reasoning (LoGAR), a verification-oriented framework that integrates VLMs into multimodal misinformation detection through explicit rationale-guided reasoning. LoGAR leverages a VLM to generate an explicit verification rationale, which serves as a global semantic anchor to condition the entire reasoning process. Concretely, the rationale functions as an active query to guide multimodal feature fusion and as a conditioning signal to modulate message passing over heterogeneous social graphs, enabling hypothesis-aware evidence aggregation. Furthermore, LoGAR introduces an instance-aware adaptive depth mechanism that dynamically determines the required reasoning depth. Experimental results on multiple multimodal misinformation benchmarks demonstrate that LoGAR consistently outperforms state-of-the-art methods while significantly reducing computational cost.

Systematic reviews (SRs) are vital for evidence-based practice in high stakes disciplines, such as healthcare, but are often impeded by intensive labors and lengthy processes that can take months to complete. Due to the high demand for domain expertise, existing automatic summarization methods fail to accurately identify relevant studies and generate high-quality summaries. To that end, we introduce InsightAgent, a human-centered interactive AI agent powered by large language models that revolutionize this workflow. InsightAgent partitions a large literature corpus based on semantics and employs a multi-agent design for more focused processing of literature, leading to significant improvement in the quality of generated SRs. InsightAgent also provides intuitive visualizations of the corpus and agent trajectories, allowing users to effortlessly monitor the actions of the agent and provide real-time feedback based on their expertise. Our user studies with 9 medical professionals demonstrate that the visualization and interaction mechanisms can effectively improve the quality of synthesized SRs by 27.2%, reaching 79.7% of human-written quality. At the same time, user satisfaction is improved by 34.4%. With InsightAgent, it only takes a clinician about 1.5 hours, rather than months, to complete a high-quality systematic review.