We introduce ChemBench, a comprehensive benchmark for evaluating LLMs’ capabilities in analytical chemistry scenarios. Unlike existing benchmarks focused on factual knowledge, ChemBench assesses model abilities to provide contextualized, practical guidance for complex analytical chemistry challenges, including instrument readiness checks, system suitability testing, method development, and troubleshooting for both liquid chromatography coupled mass spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) platforms. We evaluate three enhancement approaches: chemistry-specialized models, human-guided Chain-of-Thought reasoning, and Retrieval-Augmented Generation (RAG). Our findings reveal that general-purpose commercial models often outperform domain-specialized ones, while RAG and reasoning significantly improve performance. The six-dimension evaluation framework (specificity, correctness, usefulness, feasibility, misinformation risk, and error handling) provides valuable insights into LLMs’ real-world utility for chemistry researchers, establishing a foundation for developing more effective AI assistants for scientific research.

The shift from traditional translation to post-editing (PE) of machine-translated (MT) text can save time and reduce errors, but it also affects the design of translation interfaces, as the task changes from mainly generating text to correcting errors within otherwise helpful translation proposals. Since this paradigm shift offers potential for modalities other than mouse and keyboard, we present MMPE, the first prototype to combine traditional input modes with pen, touch, and speech modalities for PE of MT. Users can directly cross out or hand-write new text, drag and drop words for reordering, or use spoken commands to update the text in place. All text manipulations are logged in an easily interpretable format to simplify subsequent translation process research. The results of an evaluation with professional translators suggest that pen and touch interaction are suitable for deletion and reordering tasks, while speech and multi-modal combinations of select & speech are considered suitable for replacements and insertions. Overall, experiment participants were enthusiastic about the new modalities and saw them as useful extensions to mouse & keyboard, but not as a complete substitute.

Current advances in machine translation (MT) increase the need for translators to switch from traditional translation to post-editing (PE) of machine-translated text, a process that saves time and reduces errors. This affects the design of translation interfaces, as the task changes from mainly generating text to correcting errors within otherwise helpful translation proposals. Since this paradigm shift offers potential for modalities other than mouse and keyboard, we present MMPE, the first prototype to combine traditional input modes with pen, touch, and speech modalities for PE of MT. The results of an evaluation with professional translators suggest that pen and touch interaction are suitable for deletion and reordering tasks, while they are of limited use for longer insertions. On the other hand, speech and multi-modal combinations of select & speech are considered suitable for replacements and insertions but offer less potential for deletion and reordering. Overall, participants were enthusiastic about the new modalities and saw them as good extensions to mouse & keyboard, but not as a complete substitute.