The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios. To enable their safe and effective deployment in real-world healthcare settings, it is urgently necessary to benchmark the diagnostic capabilities of current models systematically. Given the limitations of existing medical benchmarks in evaluating advanced diagnostic reasoning, we present DiagnosisArena, a comprehensive and challenging benchmark designed to rigorously assess professional-level diagnostic competence. DiagnosisArena consists of 1,113 pairs of segmented patient cases and corresponding diagnoses, spanning 28 medical specialties, deriving from clinical case reports published in 10 top-tier medical journals. The benchmark is developed through a meticulous construction pipeline, involving multiple rounds of screening and review by both AI systems and human experts, with thorough checks conducted to prevent data leakage. Our study reveals that even the most advanced reasoning models, o3-mini, o1, and DeepSeek-R1, achieve only 45.82%, 31.09%, and 17.79% accuracy, respectively. This finding highlights a significant generalization bottleneck in current large language models when faced with clinical diagnostic reasoning challenges. Through DiagnosisArena, we aim to drive further advancements in AI’s diagnostic reasoning capabilities, enabling more effective solutions for real-world clinical diagnostic challenges. We openly share the benchmark and evaluation tools for further research and development.

Developing non-collaborative dialogue agents traditionally requires the manual, unscalable codification of expert strategies. We propose METRO, a method that leverages large language models to autonomously induce both strategy actions and planning logic directly from raw transcripts. METRO formalizes expert knowledge into a Strategy Forest, a hierarchical structure that captures both short-term responses (nodes) and long-term strategic foresight (branches). Experimental results across two benchmarks show that METRO demonstrates promising performance, outperforming existing methods by an average of 9%-10%. Our further analysis not only reveals the success behind METRO (strategic behavioral diversity and foresight), but also demonstrates its robust cross-task transferability. This offers new insights into building non-collaborative agents in a cost-effective and scalable way. Our code is available at https://github.com/Humphrey-0125/METRO.