With the remarkable performance of large language models (LLMs) in medicine, particularly their ability to support clinical decision-making in medical dialogues, a key limitation remains: the static reasoning patterns derived from human expert experience are often inadequate for the dynamic and diverse nature of real-world multi-turn conversations. While recent large reasoning models (such as R1) enable deeper and more complex thought processes to address such challenges, they also introduce significant redundancy. Meanwhile, recent studies on reusing atomic thoughts demonstrate a practical pathway toward dynamic and precise reasoning in general domains. In this paper, we investigate the role of atomic thought-based experience in medical dialogue tasks. First, we collect human expert clinical experience. Then, we propose a novel distillation framework that extracts atomic thoughts from teacher models and reuses them to guide reasoning and generate responses. Based on this framework, we construct training data from ReMeDi and fine-tune student models, which demonstrate enhanced performance in both static and interactive medical dialogue scenarios. Furthermore, we examine the impact of experience across various models, datasets, and scenarios. Crucially, transferring this experience empowers weaker models to generate high-quality reasoning data, matching the annotation capabilities of stronger LLMs while significantly reducing costs. The code is available in this repository https://github.com/VioletAmethystLunar/Atomic-Thoughts-Medical-Dialogue.

Medical visual question answering (MedVQA) requires models to provide accurate answers given a medical image and a corresponding question. Recently, instruction tuning of general large vision–language models (LVLMs) has become a dominant paradigm for this task, enabling open-ended predictions and effective integration of multimodal information. However, existing methods synthesize instruction data from image–caption pairs that primarily focus on visual attributes, rather than knowledge-level QA generation. This situation limits the model’s ability to learn relevant medical knowledge during training, thereby restricting its performance on MedVQA. Hence, this paper proposes MedKInstruct, which incorporates a multimodal medical knowledge graph (MMKG) to assist LVLMs in synthesizing knowledge-intensive instruction data. Additionally, we design an MMKG path–based reward function to train a stronger MedVQA model through reinforcement learning. Experimental results on the public datasets Slake and VQA-RAD show that MedKInstruct outperforms previous methods by 4.16% and 4.50%. The source code is available at the following link: https://github.com/Sonder-hang/MedKinstruct

Large language models (LLMs) have been widely adopted in healthcare, yet they still encounter significant challenges in complex clinical decision-making scenarios. Existing benchmarks primarily assess LLM performance in single-course settings and lack systematic evaluation in multi-course scenarios, where a patient’s condition evolves over time. To address this gap, we propose ClinicalMC, a benchmark for multi-course clinical decision-making. It includes 1,275 Chinese and 5,804 English samples across four stages from admission to discharge. These stages cover triage, first-course examination/diagnosis/treatment, subsequent multi-course examination/assessment/treatment, and final diagnosis. In ClinicalMC, patients in the English dataset undergo an average of 5.11 clinical courses, whereas those in the Chinese dataset undergo 3.42. To assess LLM performance, we construct a multi-agent evaluation framework that includes patient, examiner, and doctor agents. Based on the benchmark and framework, we design two experimental settings—a single-turn static setting and a multi-turn dynamic setting—and assess three categories of LLMs: 1) closed-source LLMs like GPT-4o-mini; 2) open-source LLMs like DeepSeek-V3, and 3) medical LLMs like HuatuoGPT-o1. Through extensive evaluation, we aim to better understand LLM performance in the medical domain and support its effective deployment in healthcare.