Efficient and Effective Internal Memory Retrieval for LLM-Based Healthcare Prediction

Mingchen Li, Jiatan Huang, Zonghai Yao, Hong yu


Abstract
Large language models (LLMs) hold significant promise for healthcare, yet their reliability in high-stakes clinical settings is often compromised by hallucinations and a lack of granular medical context. While Retrieval-Augmented Generation (RAG) can mitigate these issues, standard supervised pipelines require computationally intensive searches over massive external knowledge bases, leading to high latency that is impractical for time-sensitive care. To address this, we introduce Keys-to-Knowledge (K2K), a novel framework that replaces external retrieval with internal, key-based knowledge access. By encoding essential clinical information directly into the model’s parameter space, K2K enables rapid retrieval from internal key–value memory without inference-time overhead. We further enhance retrieval quality through activation-guided probe construction and cross-attention reranking. Experimental results demonstrate that K2K achieves state-of-the-art performance across four benchmark healthcare outcome prediction datasets.
Anthology ID:
2026.findings-acl.1788
Volume:
Findings of the Association for Computational Linguistics: ACL 2026
Month:
July
Year:
2026
Address:
San Diego, California, United States
Editors:
Maria Liakata, Viviane P. Moreira, Jiajun Zhang, David Jurgens
Venue:
Findings
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Publisher:
Association for Computational Linguistics
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Pages:
35895–35906
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URL:
https://preview.aclanthology.org/ingest-acl/2026.findings-acl.1788/
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Cite (ACL):
Mingchen Li, Jiatan Huang, Zonghai Yao, and Hong yu. 2026. Efficient and Effective Internal Memory Retrieval for LLM-Based Healthcare Prediction. In Findings of the Association for Computational Linguistics: ACL 2026, pages 35895–35906, San Diego, California, United States. Association for Computational Linguistics.
Cite (Informal):
Efficient and Effective Internal Memory Retrieval for LLM-Based Healthcare Prediction (Li et al., Findings 2026)
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