Uncertainty Quantification in LLM Agents: Foundations, Emerging Challenges, and Opportunities

Changdae Oh, Seongheon Park, To Eun Kim, Jiatong Li, Wendi Li, Samuel Yeh, Sean Du, Hamed Hassani, Paul Bogdan, Dawn Song, Sharon Li


Abstract
Uncertainty quantification (UQ) for large language models (LLMs) is a key building block for safety guardrails of daily LLM applications. Yet, even as LLM agents are increasingly deployed in highly complex tasks, most UQ research still centers on single-turn question-answering. We argue that UQ research must shift to realistic settings with interactive agents, and that a new principled framework for agent UQ is needed. This paper presents three pillars to build a solid ground for future agent UQ research: (1. Foundations) We present the first general formulation of agent UQ that subsumes broad classes of existing UQ setups; (2. Challenges) We identify four technical challenges specifically tied to agentic setups—selection of uncertainty estimator, uncertainty of heterogeneous entities, modeling uncertainty dynamics in interactive systems, and lack of fine-grained benchmarks—with numerical analysis on a real-world agent benchmark, 𝜏2-bench; (3. Future Directions) We conclude with noting on the practical implications of agent UQ and remaining open problems as forward-looking discussion for future explorations.
Anthology ID:
2026.acl-long.738
Volume:
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
Month:
July
Year:
2026
Address:
San Diego, California, United States
Editors:
Maria Liakata, Viviane P. Moreira, Jiajun Zhang, David Jurgens
Venue:
ACL
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Publisher:
Association for Computational Linguistics
Note:
Pages:
16219–16250
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URL:
https://preview.aclanthology.org/ingest-acl/2026.acl-long.738/
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Cite (ACL):
Changdae Oh, Seongheon Park, To Eun Kim, Jiatong Li, Wendi Li, Samuel Yeh, Sean Du, Hamed Hassani, Paul Bogdan, Dawn Song, and Sharon Li. 2026. Uncertainty Quantification in LLM Agents: Foundations, Emerging Challenges, and Opportunities. In Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 16219–16250, San Diego, California, United States. Association for Computational Linguistics.
Cite (Informal):
Uncertainty Quantification in LLM Agents: Foundations, Emerging Challenges, and Opportunities (Oh et al., ACL 2026)
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https://preview.aclanthology.org/ingest-acl/2026.acl-long.738.pdf
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