MediEval: A Unified Medical Benchmark for Patient-Contextual and Knowledge-Grounded Reasoning in LLMs

Zhan Qu, Michael F\"arber


Abstract
Large Language Models (LLMs) are increasingly applied to medicine, yet their adoption is limited by concerns over reliability and safety. Existing evaluations either test factual medical knowledge in isolation or assess patient-level reasoning without verifying correctness, leaving a critical gap. We introduce MediEval, a benchmark that links MIMIC-IV electronic health records (EHRs) to a unified knowledge base built from UMLS and other biomedical vocabularies. MediEval generates diverse factual and counterfactual medical statements within real patient contexts, enabling systematic evaluation across a 4-quadrant framework that jointly considers knowledge grounding and contextual consistency. Using this framework, we identify critical failure modes, including hallucinated support and truth inversion, that current proprietary, open-source, and domain-specific LLMs frequently exhibit. To address these risks, we propose Counterfactual Risk-Aware Fine-tuning (CoRFu), a DPO-based method with an asymmetric penalty targeting unsafe confusions. CoRFu improves by +16.4 macro-F1 points over the base model and eliminates truth inversion errors, demonstrating both higher accuracy and substantially greater safety.
Anthology ID:
2026.acl-long.734
Volume:
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
Month:
July
Year:
2026
Address:
San Diego, California, United States
Editors:
Maria Liakata, Viviane P. Moreira, Jiajun Zhang, David Jurgens
Venue:
ACL
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Publisher:
Association for Computational Linguistics
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Pages:
16150–16164
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URL:
https://preview.aclanthology.org/ingest-acl/2026.acl-long.734/
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Cite (ACL):
Zhan Qu and Michael F\"arber. 2026. MediEval: A Unified Medical Benchmark for Patient-Contextual and Knowledge-Grounded Reasoning in LLMs. In Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 16150–16164, San Diego, California, United States. Association for Computational Linguistics.
Cite (Informal):
MediEval: A Unified Medical Benchmark for Patient-Contextual and Knowledge-Grounded Reasoning in LLMs (Qu & F"arber, ACL 2026)
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https://preview.aclanthology.org/ingest-acl/2026.acl-long.734.pdf
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