EvoSci: A Bio-Inspired Multi-Agent Framework for the Evolution of Scientific Discovery

Xiaoyu Xiong, Yuqi Ren, Deyi Xiong


Abstract
Large language models (LLMs), have shown strong potential in scientific discovery, yet existing methods still face substantial challenges in the design of research workflows and multi-role collaboration mechanisms. To mitigate these issues, we propose EvoSci, a multi-agent scientific collaboration framework, which integrates bio-inspired evolution with knowledge graph modeling. To iteratively generate, evaluate, and refine research ideas, EvoSci incorporates multiple role-based agents, including mentor, researcher, and reviewer. By combining collaborative reasoning, shared memory, and evolutionary feedback, EvoSci significantly enhances the coherence and creativity of scientific exploration. Experiments on real-world research topics demonstrate that EvoSci significantly outperforms strong baselines in LLM-based structured peer-review and comparative ranking evaluations, achieving the highest overall peer-review score (ICLR 4.90) and top ranking (Top-10 = 54). These results suggest its superiority in both scientific idea generation and continuous discovery.
Anthology ID:
2026.acl-long.447
Volume:
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
Month:
July
Year:
2026
Address:
San Diego, California, United States
Editors:
Maria Liakata, Viviane P. Moreira, Jiajun Zhang, David Jurgens
Venue:
ACL
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
9846–9878
Language:
URL:
https://preview.aclanthology.org/ingest-acl/2026.acl-long.447/
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Bibkey:
Cite (ACL):
Xiaoyu Xiong, Yuqi Ren, and Deyi Xiong. 2026. EvoSci: A Bio-Inspired Multi-Agent Framework for the Evolution of Scientific Discovery. In Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 9846–9878, San Diego, California, United States. Association for Computational Linguistics.
Cite (Informal):
EvoSci: A Bio-Inspired Multi-Agent Framework for the Evolution of Scientific Discovery (Xiong et al., ACL 2026)
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https://preview.aclanthology.org/ingest-acl/2026.acl-long.447.pdf
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