@inproceedings{liu-etal-2026-bioproagent,
    title = "{B}io{P}ro{A}gent: Neuro-Symbolic Grounding for Constrained Scientific Planning",
    author = "Liu, Yuyang  and
      Wang, Jingya  and
      Lv, Liuzhenghao  and
      Tian, Yonghong",
    editor = "Liakata, Maria  and
      Moreira, Viviane P.  and
      Zhang, Jiajun  and
      Jurgens, David",
    booktitle = "Proceedings of the 64th Annual Meeting of the {A}ssociation for {C}omputational {L}inguistics (Volume 1: Long Papers)",
    month = jul,
    year = "2026",
    address = "San Diego, California, United States",
    publisher = "Association for Computational Linguistics",
    url = "https://preview.aclanthology.org/ingest-acl/2026.acl-long.1981/",
    pages = "42764--42783",
    ISBN = "979-8-89176-390-6",
    abstract = "Large language models (LLMs) have demonstrated significant reasoning capabilities in scientific discovery but struggle to bridge the gap to physical execution in wet-labs. In these irreversible environments, probabilistic hallucinations are not merely incorrect; they can cause equipment damage or experimental failure. To address this, we propose \textbf{BioProAgent}, a neuro-symbolic framework that anchors probabilistic planning in a deterministic Finite State Machine (FSM). We introduce a State-Augmented Planning mechanism that enforces a rigorous \textit{Design-Verify-Rectify} workflow, ensuring hardware compliance before execution. Furthermore, we address the context bottleneck inherent in complex device schemas by \textit{Semantic Symbol Grounding}, reducing token consumption by $\sim$6$\times$ through symbolic abstraction. In the extended BioProBench benchmark, BioProAgent achieves 95.6{\%} physical compliance (compared to 21.0{\%} for ReAct), demonstrating that neuro-symbolic constraints are essential for reliable autonomy in irreversible physical environments. Code at https://github.com/YuyangSunshine/bioproagent and Website at https://yuyangsunshine.github.io/BioPro-Project/ ."
}