MMCLIP: Cross-Modal Attention Masked Modelling for Medical Language-Image Pre-Training
Biao Wu, Yutong Xie, Zeyu Zhang, Vu Minh Hieu Phan, Qi Chen, Ling Chen, Qi Wu
Abstract
Vision-and-language pretraining (VLP) in medicine leverages contrastive learning on image–text pairs, often enhanced with masked modeling. However, existing methods face two challenges: difficulty reconstructing key pathological features due to limited data, and reliance on either paired or image-only datasets without combining both. To address this, we propose **MMCLIP** (**M**asked **M**edical **C**ontrastive **L**anguage–**I**mage **P**re-training), which introduces two modules: **AttMIM**: Masks image features highly correlated with text to improve reconstruction of fine medical details. **EntMLM**: Masks key medical entities in text and reconstructs them using visual cues. Furthermore, **MMCLIP** incorporates unpaired data through disease-kind prompts, achieving state-of-the-art performance in zero-shot and fine-tuning across five benchmarks.- Anthology ID:
- 2026.acl-long.113
- Volume:
- Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
- Month:
- July
- Year:
- 2026
- Address:
- San Diego, California, United States
- Editors:
- Maria Liakata, Viviane P. Moreira, Jiajun Zhang, David Jurgens
- Venue:
- ACL
- SIG:
- Publisher:
- Association for Computational Linguistics
- Note:
- Pages:
- 2440–2455
- Language:
- URL:
- https://preview.aclanthology.org/ingest-acl/2026.acl-long.113/
- DOI:
- Cite (ACL):
- Biao Wu, Yutong Xie, Zeyu Zhang, Vu Minh Hieu Phan, Qi Chen, Ling Chen, and Qi Wu. 2026. MMCLIP: Cross-Modal Attention Masked Modelling for Medical Language-Image Pre-Training. In Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 2440–2455, San Diego, California, United States. Association for Computational Linguistics.
- Cite (Informal):
- MMCLIP: Cross-Modal Attention Masked Modelling for Medical Language-Image Pre-Training (Wu et al., ACL 2026)
- PDF:
- https://preview.aclanthology.org/ingest-acl/2026.acl-long.113.pdf