MMCLIP: Cross-Modal Attention Masked Modelling for Medical Language-Image Pre-Training

Biao Wu, Yutong Xie, Zeyu Zhang, Vu Minh Hieu Phan, Qi Chen, Ling Chen, Qi Wu


Abstract
Vision-and-language pretraining (VLP) in medicine leverages contrastive learning on image–text pairs, often enhanced with masked modeling. However, existing methods face two challenges: difficulty reconstructing key pathological features due to limited data, and reliance on either paired or image-only datasets without combining both. To address this, we propose **MMCLIP** (**M**asked **M**edical **C**ontrastive **L**anguage–**I**mage **P**re-training), which introduces two modules: **AttMIM**: Masks image features highly correlated with text to improve reconstruction of fine medical details. **EntMLM**: Masks key medical entities in text and reconstructs them using visual cues. Furthermore, **MMCLIP** incorporates unpaired data through disease-kind prompts, achieving state-of-the-art performance in zero-shot and fine-tuning across five benchmarks.
Anthology ID:
2026.acl-long.113
Volume:
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
Month:
July
Year:
2026
Address:
San Diego, California, United States
Editors:
Maria Liakata, Viviane P. Moreira, Jiajun Zhang, David Jurgens
Venue:
ACL
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Publisher:
Association for Computational Linguistics
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Pages:
2440–2455
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URL:
https://preview.aclanthology.org/ingest-acl/2026.acl-long.113/
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Cite (ACL):
Biao Wu, Yutong Xie, Zeyu Zhang, Vu Minh Hieu Phan, Qi Chen, Ling Chen, and Qi Wu. 2026. MMCLIP: Cross-Modal Attention Masked Modelling for Medical Language-Image Pre-Training. In Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 2440–2455, San Diego, California, United States. Association for Computational Linguistics.
Cite (Informal):
MMCLIP: Cross-Modal Attention Masked Modelling for Medical Language-Image Pre-Training (Wu et al., ACL 2026)
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https://preview.aclanthology.org/ingest-acl/2026.acl-long.113.pdf
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