Personalized glucose regulation remains a central yet unresolved challenge in precision nutrition, as postprandial glucose response varies substantially across individuals. Existing approaches based on glycemic indices fail to adequately account for such heterogeneity and lack the mechanism to dynamically adjust meals based on personal physiological feedback. In this context, recent advances in LLM-based agents offer a promising direction, as they enable context-aware reasoning and iterative refinement. Inspired by this, we propose a physio-feedback agentic loop, a unified system that integrates individualized absorption modeling with dietary intervention to regulate glucose response. Specifically, we develop a Physiology-Aware Glucose Predictor to model individualized absorption dynamics through a learnable Temporal Physiological Absorption Decay Module. We then construct a Prediction-Driven Two-Stage Meal Optimization Agent that iteratively refines real-world meals using predicted outcomes as explicit feedback. Through extensive experiments on multiple public datasets, we demonstrate that our method not only improves prediction accuracy but also effectively reduces glucose excursions. To the best of our knowledge, this paper marks the first step in integrating physiological learning with an LLM-based agent for personalized glucose regulation.

Massive Open Online Courses (MOOCs) have developed rapidly and attracted large number of learners. In this work, we present MAssistant system, a personal knowledge assistant for MOOC learners. MAssistant helps users to trace the concepts they have learned in MOOCs, and to build their own concept graphs. There are three key components in MAssistant: (i) a large-scale concept graph built from open data sources, which contains concepts in various domains and relations among them; (ii) a browser extension which interacts with learners when they are watching video lectures, and presents important concepts to them; (iii) a web application allowing users to explore their personal concept graphs, which are built based on their learning activities on MOOCs. MAssistant will facilitate the knowledge management task for MOOC learners, and make the learning on MOOCs easier.