Guanyu Tao
2026
Operation-Mechanism Alignment for Reliable Clinical Reasoning over Electronic Health Records
Guanyu Tao | Siyao Wang | Yong Xue | Ashwani Tanwar | Yuting Ji | Kai Sun | Monica Mok | Marzana Chowdhury | Deepa Gupta | Ashok Gupta | Jingqing Zhang | Vibhor Gupta | Yike Guo
BioNLP 2026
Guanyu Tao | Siyao Wang | Yong Xue | Ashwani Tanwar | Yuting Ji | Kai Sun | Monica Mok | Marzana Chowdhury | Deepa Gupta | Ashok Gupta | Jingqing Zhang | Vibhor Gupta | Yike Guo
BioNLP 2026
Clinical reasoning over electronic health records (EHRs) involves heterogeneous operations, including text interpretation, numerical computation, temporal filtering, and guideline-based aggregation. However, many existing LLM-based approaches still cast these heterogeneous operations as a single end-to-end generation process, obscuring their different reliability requirements and making intermediate failures difficult to inspect. We therefore propose a framework based on operation-mechanism alignment that represents clinical reasoning as a directed acyclic graph of typed operations, where each node is assigned to the execution mechanism best suited to its reliability requirements. The framework also preserves structured evidence provenance for intermediate results. Across six clinician-annotated binary decision tasks, the framework outperforms direct prompting, single-step retrieval-augmented prompting, and chain-of-thought baselines, supporting operation-mechanism alignment as a practical design principle for reliable clinical reasoning over EHRs.