Lossless compression has made significant advancements in Genomics Data (GD) storage, sharing and management. Current learning-based methods are non-evolvable with problems of low-level compression modeling, limited adaptability, and user-unfriendly interface. To this end, we propose AgentGC, the first evolutionary Agent-based GD Compressor, consisting of 3 layers with multi-agent named Leader and Worker. Specifically, the 1) User layer provides a user-friendly interface via Leader combined with LLM; 2) Cognitive layer, driven by the Leader, integrates LLM to consider joint optimization of algorithm-dataset-system, addressing the issues of low-level modeling and limited adaptability; and 3) Compression layer, headed by Worker, performs compression decompression via a automated multi-knowledge learning-based compression framework. On top of AgentGC, we design 3 modes to support diverse scenarios: CP for compression-ratio priority, TP for throughput priority, and BM for balanced mode. Compared with 14 baselines on 9 datasets, the average compression ratios gains are 16.66%, 16.11%, and 16.33%, the throughput gains are 4.73x, 9.23x, and 9.15x, respectively.

Vision-Language Models (VLMs) are powerful yet computationally intensive for widespread practical deployments. To address such challenge without costly re-training, post-training acceleration techniques like quantization and token reduction are extensively explored. However, current acceleration evaluations primarily target minimal overall performance degradation, overlooking a crucial question: does the accelerated model still give the same answers to the same questions as it did before acceleration? This is vital for stability-centered industrial applications where consistently correct answers for specific, known situations are paramount, such as in AI-based disease diagnosis. We systematically investigate this for accelerated VLMs, testing four leading models (LLaVA-1.5, LLaVA-Next, Qwen2-VL, Qwen2.5-VL) with eight acceleration methods on ten multi-modal benchmarks. Our findings are stark: despite minimal aggregate performance drops, accelerated models changed original answers up to 20% of the time. Critically, up to 6.5% of these changes converted correct answers to incorrect. Input perturbations magnified these inconsistencies, and the trend is confirmed by case studies with the medical VLM LLaVA-Med. This research reveals a significant oversight in VLM acceleration, stressing an urgent need for instance-level stability checks to ensure trustworthy real-world deployment.