@inproceedings{chu-fuhr-2026-crossddi,
    title = "{C}ross{DDI}: Cross-Source Evidence-Grounded Drug-Drug Interaction Verification",
    author = "Chu, Bohao  and
      Fuhr, Norbert",
    editor = "Demner-Fushman, Dina  and
      Ananiadou, Sophia  and
      Roberts, Kirk  and
      Tsujii, Junichi",
    booktitle = "{B}io{NLP} 2026",
    month = jul,
    year = "2026",
    address = "San Diego, California",
    publisher = "Association for Computational Linguistics",
    url = "https://preview.aclanthology.org/ingest-acl-workshops/2026.bionlp-1.73/",
    pages = "911--919",
    ISBN = "979-8-89176-434-7",
    abstract = "LLM-based drug{--}drug interaction (DDI) assessment remains difficult to audit when predictions are not explicitly tied to evidence. While retrieval-augmented generation (RAG) improves grounding, predictions are not guaranteed to be entailed by retrieved items. We present CrossDDI, a verification-first framework that separates LLM-based evidence extraction from deterministic, LLM-free arbitration over DrugBank and PubMed, requiring positive predictions to be linked to explicit supporting evidence. Evaluated on 1,000 DDInter 2.0 pairs under a positive{--}unlabeled setting, CrossDDI achieves recall of 0.576{--}0.593 over confirmed positives with interaction prediction rates comparable to RAG, while reducing cross-backbone variation (0.018 vs. 0.066). Analysis identifies literature evidence acquisition and attribution as the primary bottleneck: PubMed retrieval covers only 40.5{\%} of confirmed positives, and Path B-only evidence is substantially less reliable than structured evidence. These results suggest that verification-first architectures can improve traceability and backbone consistency, while broader and more reliable literature evidence is needed to extend coverage beyond structured sources."
}