Divide-Prompt-Refine: a Training-Free, Structure-Aware Framework for Biomedical Abstract Generation

Sylvey Lin, Joseph Menke, Shufan Ming, Dongin Nam, Neil Smalheiser, Halil Kilicoglu


Abstract
Biomedical abstracts play a critical role in downstream NLP applications, such as information retrieval, biocuration, and biomedical knowledge discovery. However, a non-trivial number of biomedical articles do not have abstracts, diminishing the utility of these articles for downstream tasks. We propose DPR-BAG (Divide, Prompt, and Refine for Biomedical Abstract Generation), a training-free, zero-shot framework that generates coherent and factually grounded abstracts for biomedical articles with full text but no abstract. DPR-BAG decomposes full-text documents into structured rhetorical facets following the Background-Objective-Methods-Results-Conclusions (BOMRC) schema, performs parallel LLM-based summarization for each facet, and applies a final refinement stage to restore global discourse coherence. On PMC-MAD, a distribution-aligned dataset of 46,309 biomedical articles, DPR-BAG improves abstractive novelty over strong extractive and fine-tuned baselines, while maintaining factual consistency. Our ablation study reveals a counterintuitive finding: increasing prompt complexity or explicitly injecting entity-level guidance can degrade factual alignment, highlighting the importance of controlled prompting strategies. These findings underscore the potential of training-free, structure-aware frameworks for scalable biomedical abstract generation in low-resource settings. Our data and code are available at https://huggingface.co/datasets/pmc-mad/PMC-MAD and https://github.com/ScienceNLP-Lab/MultiTagger-v2/tree/main/DPR-BAG.
Anthology ID:
2026.bionlp-1.64
Volume:
BioNLP 2026
Month:
July
Year:
2026
Address:
San Diego, California
Editors:
Dina Demner-Fushman, Sophia Ananiadou, Kirk Roberts, Junichi Tsujii
Venues:
BioNLP | WS
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
770–790
Language:
URL:
https://preview.aclanthology.org/ingest-acl-workshops/2026.bionlp-1.64/
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Bibkey:
Cite (ACL):
Sylvey Lin, Joseph Menke, Shufan Ming, Dongin Nam, Neil Smalheiser, and Halil Kilicoglu. 2026. Divide-Prompt-Refine: a Training-Free, Structure-Aware Framework for Biomedical Abstract Generation. In BioNLP 2026, pages 770–790, San Diego, California. Association for Computational Linguistics.
Cite (Informal):
Divide-Prompt-Refine: a Training-Free, Structure-Aware Framework for Biomedical Abstract Generation (Lin et al., BioNLP 2026)
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PDF:
https://preview.aclanthology.org/ingest-acl-workshops/2026.bionlp-1.64.pdf