Clinical Evidence and Patient Reviews: A Linked Dataset for Antidepressant Side Effects

Steven Au


Abstract
Clinical sources and patient-authored reviews often describe antidepressant side effects in different ways, but these differences are rarely measured directly. We present ClinPeer-AE, a linked dataset for comparing side-effect evidence from PubMed, ClinicalTrials.gov, WebMD, and Drugs.com while preserving source identity. Across five widely prescribed antidepressants, we find low overlap between clinical and peer sources, large differences in relative emphasis, and evidence that many peer-only effects also appear in U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) reports. These findings suggest that patient reviews provide useful context about recurring medication experiences and offer a complementary view of how side effects are described outside formal clinical settings.
Anthology ID:
2026.bionlp-1.52
Volume:
BioNLP 2026
Month:
July
Year:
2026
Address:
San Diego, California
Editors:
Dina Demner-Fushman, Sophia Ananiadou, Kirk Roberts, Junichi Tsujii
Venues:
BioNLP | WS
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
656–664
Language:
URL:
https://preview.aclanthology.org/ingest-acl-workshops/2026.bionlp-1.52/
DOI:
Bibkey:
Cite (ACL):
Steven Au. 2026. Clinical Evidence and Patient Reviews: A Linked Dataset for Antidepressant Side Effects. In BioNLP 2026, pages 656–664, San Diego, California. Association for Computational Linguistics.
Cite (Informal):
Clinical Evidence and Patient Reviews: A Linked Dataset for Antidepressant Side Effects (Au, BioNLP 2026)
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PDF:
https://preview.aclanthology.org/ingest-acl-workshops/2026.bionlp-1.52.pdf