Research suggests that using generic language models in specialized domains may be sub-optimal due to significant domain differences. As a result, various strategies for developing domain-specific language models have been proposed, including techniques for adapting an existing generic language model to the target domain, e.g. through various forms of vocabulary modifications and continued domain-adaptive pretraining with in-domain data. Here, an empirical investigation is carried out in which various strategies for adapting a generic language model to the clinical domain are compared to pretraining a pure clinical language model. Three clinical language models for Swedish, pretrained for up to ten epochs, are fine-tuned and evaluated on several downstream tasks in the clinical domain. A comparison of the language models’ downstream performance over the training epochs is conducted. The results show that the domain-specific language models outperform a general-domain language model; however, there is little difference in performance of the various clinical language models. However, compared to pretraining a pure clinical language model with only in-domain data, leveraging and adapting an existing general-domain language model requires fewer epochs of pretraining with in-domain data.

Automatic de-identification is a cost-effective and straightforward way of removing large amounts of personally identifiable information from large and sensitive corpora. However, these systems also introduce errors into datasets due to their imperfect precision. These corruptions of the data may negatively impact the utility of the de-identified dataset. This paper de-identifies a very large clinical corpus in Swedish either by removing entire sentences containing sensitive data or by replacing sensitive words with realistic surrogates. These two datasets are used to perform domain adaptation of a general Swedish BERT model. The impact of the de-identification techniques is assessed by training and evaluating the models using six clinical downstream tasks. The results are then compared to a similar BERT model domain-adapted using an unaltered version of the clinical corpus. The results show that using an automatically de-identified corpus for domain adaptation does not negatively impact downstream performance. We argue that automatic de-identification is an efficient way of reducing the privacy risks of domain-adapted models and that the models created in this paper should be safe to distribute to other academic researchers.

The use of pretrained language models, fine-tuned to perform a specific downstream task, has become widespread in NLP. Using a generic language model in specialized domains may, however, be sub-optimal due to differences in language use and vocabulary. In this paper, it is investigated whether an existing, generic language model for Swedish can be improved for the clinical domain through continued pretraining with clinical text. The generic and domain-specific language models are fine-tuned and evaluated on three representative clinical NLP tasks: (i) identifying protected health information, (ii) assigning ICD-10 diagnosis codes to discharge summaries, and (iii) sentence-level uncertainty prediction. The results show that continued pretraining on in-domain data leads to improved performance on all three downstream tasks, indicating that there is a potential added value of domain-specific language models for clinical NLP.

The International Classification of Diseases (ICD) is a system for systematically recording patients’ diagnoses. Clinicians or professional coders assign ICD codes to patients’ medical records to facilitate funding, research, and administration. In most health facilities, clinical coding is a manual, time-demanding task that is prone to errors. A tool that automatically assigns ICD codes to free-text clinical notes could save time and reduce erroneous coding. While many previous studies have focused on ICD coding, research on Swedish patient records is scarce. This study explored different approaches to pairing Swedish clinical notes with ICD codes. KB-BERT, a BERT model pre-trained on Swedish text, was compared to the traditional supervised learning models Support Vector Machines, Decision Trees, and K-nearest Neighbours used as the baseline. When considering ICD codes grouped into ten blocks, the KB-BERT was superior to the baseline models, obtaining an F1-micro of 0.80 and an F1-macro of 0.58. When considering the 263 full ICD codes, the KB-BERT was outperformed by all baseline models at an F1-micro and F1-macro of zero. Wilcoxon signed-rank tests showed that the performance differences between the KB-BERT and the baseline models were statistically significant.