Large Language Models infuse newfound vigor into the advancement of the medical domain, yet the scarcity of data poses a significant bottleneck hindering community progress. In this paper, we release the largest ever medical Question Answering (QA) dataset with 26 Million QA pairs named Huatuo-26M. We benchmark many existing approaches in our dataset in terms of both retrieval and generation. We also experimentally show the benefit of the proposed dataset in many aspects: (i) it serves as a fine-tuning data for training medical Large Language Models (LLMs); (ii) it works as an external knowledge source for retrieval-augmented generation (RAG); (iii) it demonstrates transferability by enhancing zero-shot performance on other QA datasets; and (iv) it aids in training biomedical model as a pre-training corpus. Our empirical findings substantiate the dataset’s utility in these domains, thereby confirming its significance as a resource in the medical QA landscape.

Language is the principal tool for human communication, in which humor is one of the most attractive parts. Producing natural language like humans using computers, a.k.a, Natural Language Generation (NLG), has been widely used for dialogue systems, chatbots, machine translation, as well as computer-aid creation e.g., idea generations, scriptwriting. However, the humor aspect of natural language is relatively under-investigated, especially in the age of pre-trained language models. In this work, we aim to preliminarily test *whether NLG can generate humor as humans do*. We build a largest dataset consisting of numerous **C**hinese **C**omical **C**rosstalk scripts (called **C**3 in short), which is for a popular Chinese performing art called ‘Xiangsheng’ or ‘相声’ since 1800s.We benchmark various generation approaches including training-from-scratch Seq2seq, fine-tuned middle-scale PLMs, and large-scale PLMs (with and without fine-tuning). Moreover, we also conduct a human assessment, showing that 1) *large-scale pretraining largely improves crosstalk generation quality*; and 2) *even the scripts generated from the best PLM is far from what we expect*. We conclude humor generation could be largely improved using large-scaled PLMs, but it is still in its infancy. The data and benchmarking code are publicly available in [https://github.com/anonNo2/crosstalk-generation](https://github.com/anonNo2/crosstalk-generation).

In this paper, we present HuatuoGPT, a Large Language Model (LLM) for medical consultation. The core recipe of HuatuoGPT is to leverage both distilled data from **ChatGPT** and real-world data from **doctors** in the supervised fine-tuning stage. This is not only because purely using **ChatGPT**-distilled data might cause ‘model collapse’, but also because real-world data from **doctors** would be complementary to **ChatGPT**-distilled data. The responses from ChatGPT are usually detailed, well-presented, fluent, and instruction-followed, but it cannot perform like a doctor in many aspects, e.g. for interactive diagnosis. Therefore, the extra doctors’ data could tame a distilled language model to perform like doctors. To synergize the strengths of both data sources, we introduce RLMF (Reinforcement Learning from Mixed Feedback) where a reward model is trained to align the language model with the merits that both sources (ChatGPT and doctors) bring. Experimental results (in GPT-4 evaluation, human evaluation, and medical benchmark datasets) demonstrate that HuatuoGPT achieves state-of-the-art results in performing medical consultation among open-source LLMs. It is worth noting that by using additional real-world data and RLMF, the distilled language model (i.e., HuatuoGPT) outperforms its teacher model (i.e., ChatGPT) in most cases.