Document-level relation extraction (DocRE) aims to extract structured relational triples from unstructured text based on given entities. Existing methods are mainly categorized into transformer-based models and graph-based models. While transformer-based models capture global contextual information, they typically focus on individual entity pairs, making it challenging to capture complex interactions between multiple entity pairs. Graph-based models build document graphs using entities or sentences as nodes for reasoning but often lack explicit mechanisms to model fine-grained interactions between entity pairs, limiting their ability to handle complex relational reasoning tasks. Additionally, previous research has not considered predicting all possible relations in advance to assist with DocRE tasks. To address these issues, we propose a new framework namely **GREP** (**g**lobal **r**elations and **e**ntity **p**air reasoning) for DocRE tasks. GREP leverages the global interdependencies between entity pairs to capture fine-grained interactions and perform multi reasoning at the entity pair level. In addtion, GREP for the first time proposes an auxiliary task that predicts all possible relations in advance that exist in a document, which enables the model to filter out the most unlikely relations. Experimental results on widely-used datasets demonstrate that our model achieves state-of-the-art performance. Code is available at https://github.com/yanyi74/GREP.

Document-level Relation Extraction (DocRE) aims to extract relations between entity pairs in a document and poses many challenges as it involves multiple mentions of entities and cross-sentence inference. However, several aspects that are important for DocRE have not been considered and explored. Existing work ignores bidirectional mention interaction when generating relational features for entity pairs. Also, sophisticated neural networks are typically designed for cross-sentence evidence extraction to further enhance DocRE. More interestingly, we reveal a noteworthy finding: If a model has predicted a relation between an entity and other entities, this relation information may help infer and predict more relations between the entity’s adjacent entities and these other entities. Nonetheless, none of existing methods leverage secondary reasoning to exploit results of relation prediction. To this end, we propose a novel Secondary Reasoning Framework (SRF) for DocRE. In SRF, we initially propose a DocRE model that incorporates bidirectional mention fusion and a simple yet effective evidence extraction module (incurring only an additional learnable parameter overhead) for relation prediction. Further, for the first time, we elaborately design and propose a novel secondary reasoning method to discover more relations by exploring the results of the first relation prediction. Extensive experiments show that SRF achieves SOTA performance and our secondary reasoning method is both effective and general when integrated into existing models.