Most affective computing research treats emotion as a static property of text, focusing on the writer’s sentiment while overlooking the reader’s perspective. This approach ignores how individual personalities lead to diverse emotional appraisals of the same event. Although role-playing Large Language Models (LLMs) attempt to simulate such nuanced reactions, they often suffer from "personality illusion”—relying on surface-level stereotypes rather than authentic cognitive logic. A critical bottleneck is the absence of ground-truth human data to link personality traits to emotional shifts. To bridge the gap, we introduce Persona-E² (Persona-Event2Emotion), a large-scale dataset grounded in annotated MBTI and Big Five traits to capture reader-based emotional variations across news, social media, and life narratives. Extensive experiments reveal that state-of-the-art LLMs struggle to capture precise appraisal shifts, particularly in social media domains. Crucially, we find that personality information significantly improves comprehension, with the Big Five traits alleviating "personality illusion.’

The automation of scientific research through large language models (LLMs) presents significant opportunities but faces critical challenges in knowledge synthesis and quality assurance. We introduce Feedback-Refined Agent Methodology (FRAME), a novel framework that enhances medical paper generation through iterative refinement and structured feedback. Our approach comprises three key innovations: (1) A structured dataset construction method that decomposes 4,287 medical papers into essential research components through iterative refinement; (2) A tripartite architecture integrating Generator, Evaluator, and Reflector agents that progressively improve content quality through metric-driven feedback; and (3) A comprehensive evaluation framework that combines statistical metrics with human-grounded benchmarks. Experimental results demonstrate FRAME’s effectiveness, achieving significant improvements over conventional approaches across multiple models (9.91% average gain with DeepSeek V3, comparable improvements with GPT-4o Mini) and evaluation dimensions. Human evaluation confirms that FRAME-generated papers achieve quality comparable to human-authored works, with particular strength in synthesizing future research directions. The results demonstrated our work could efficiently assist medical research by building a robust foundation for automated medical research paper generation while maintaining rigorous academic standards.