Protein Language Models traditionally depend on Multiple Sequence Alignments (MSA) to incorporate evolutionary knowledge. However, MSA-based approaches suffer from substantial computational overhead and generally underperform in generalizing to de novo proteins. This study reevaluates the role of MSA, proposing it as a retrieval augmentation method and questioning the necessity of sequence alignment. We show that a simple alternative, Retrieved Sequence Augmentation (RSA), can enhance protein representation learning without the need for alignment and cumbersome preprocessing. RSA surpasses MSA Transformer by an average of 5% in both structural and property prediction tasks while being 373 times faster. Additionally, RSA demonstrates enhanced transferability for predicting de novo proteins. This methodology addresses a critical need for efficiency in protein prediction and can be rapidly employed to identify homologous sequences, improve representation learning, and enhance the capacity of Large Language Models to interpret protein structures.

Multimodal reasoning stands as a pivotal capability for large vision-language models (LVLMs). The integration with Domain-Specific Languages (DSL), offering precise visual representations, equips these models with the opportunity to execute more accurate reasoning in complex and professional domains. However, the vanilla Chain-of-Thought (CoT) prompting method faces challenges in effectively leveraging the unique strengths of visual and DSL representations, primarily due to their differing reasoning mechanisms. Additionally, it often falls short in addressing critical steps in multi-step reasoning tasks. To mitigate these challenges, we introduce the Bi-Modal Behavioral Alignment (BBA) prompting method, designed to maximize the potential of DSL in augmenting complex multi-modal reasoning tasks. This method initiates by guiding LVLMs to create separate reasoning chains for visual and DSL representations. Subsequently, it aligns these chains by addressing any inconsistencies, thus achieving a cohesive integration of behaviors from different modalities. Our experiments demonstrate that BBA substantially improves the performance of GPT-4V(ision) on geometry problem solving (28.34% → 34.22%), chess positional advantage prediction (42.08% → 46.99%) and molecular property prediction (77.47% → 83.52%).

Large language models (LLMs) have achieved human-level text generation, emphasizing the need for effective deepfake text detection to mitigate risks like the spread of fake news and plagiarism. Existing research has been constrained by evaluating detection methods o specific domains or particular language models. In practical scenarios, however, the detector faces texts from various domains or LLMs without knowing their sources. To this end, we build a comprehensive testbed by gathering texts from diverse human writings and deepfake texts generated by different LLMs. Empirical results on mainstream detection methods demonstrate the difficulties associated with detecting deepfake text in a wide-ranging testbed, particularly in out-of-distribution scenarios. Such difficulties align with the diminishing linguistic differences between the two text sources. Despite challenges, the top-performing detector can identify 84.12% out-of-domain texts generated by a new LLM, indicating the feasibility for application scenarios.

Large language models (LLMs) have achieved impressive performance across various mathematical reasoning benchmarks. However, there are increasing debates regarding whether these models truly understand and apply mathematical knowledge or merely rely on shortcuts for mathematical reasoning. One essential and frequently occurring evidence is that when the math questions are slightly changed, LLMs can behave incorrectly. This motivates us to evaluate the robustness of LLMs’ math reasoning capability by testing a wide range of question variations. We introduce the adversarial grade school math (GSM-Plus) dataset, an extension of GSM8K augmented with various mathematical perturbations. Our experiments on 25 LLMs and 4 prompting techniques show that while LLMs exhibit different levels of math reasoning abilities, their performances are far from robust. In particular, even for problems that have been solved in GSM8K, LLMs can make mistakes when new statements are added or the question targets are altered. We also explore whether more robust performance can be achieved by composing existing prompting methods, in which we try an iterative method that generates and verifies each intermediate thought based on its reasoning goal and calculation result.

When communicating with elders with cognitive impairment, cognitive stimulation (CS) help to maintain the cognitive health of elders. Data sparsity is the main challenge in building CS-based dialogue systems, particularly in the Chinese language. To fill this gap, we construct a Chinese CS conversation (CSConv) dataset, which contains about 2.6K groups of dialogues with therapy principles and emotional support strategy labels. Making chit chat while providing emotional support is overlooked by the majority of existing cognitive dialogue systems. In this paper, we propose a multi-source knowledge fusion method for CS dialogue (CSD), to generate open-ended responses guided by the therapy principle and emotional support strategy. We first use a progressive mask method based on external knowledge to learn encoders as effective classifiers, which is the prerequisite to predict the therapy principle and emotional support strategy of the target response. Then a decoder interacts with the perceived therapy principle and emotional support strategy to generate responses. Extensive experiments conducted on the CSConv dataset demonstrate the effectiveness of the proposed method, while there is still a large space for improvement compared to human performance.

Explaining the black-box predictions of NLP models naturally and accurately is an important open problem in natural language generation. These free-text explanations are expected to contain sufficient and carefully-selected evidence to form supportive arguments for predictions. Thanks to the superior generative capacity of large pretrained language models (PLM), recent work built on prompt engineering enables explanations generated without specific training. However, explanations generated through single-pass prompting often lack sufficiency and conciseness, due to the prompt complexity and hallucination issues. To discard the dross and take the essence of current PLM’s results, we propose to produce sufficient and concise explanations via the information bottleneck (EIB) theory. EIB regenerates explanations by polishing the single-pass output of PLM but retaining the information that supports the contents being explained by balancing two information bottleneck objectives. Experiments on two different tasks verify the effectiveness of EIB through automatic evaluation and thoroughly-conducted human evaluation.

There is a growing interest in dataset generation recently due to the superior generative capacity of large pre-trained language models (PLMs). In this paper, we study a flexible and efficient zero-short learning method, ZeroGen.Given a zero-shot task, we first generate a dataset from scratch using PLMs in an unsupervised manner. Then, we train a tiny task model (e.g., LSTM) under the supervision of the synthesized dataset. This approach allows highly efficient inference as the final task model only has orders of magnitude fewer parameters comparing to PLMs (e.g., GPT2-XL).Apart from being annotation-free and efficient, we argue that ZeroGen can also provide useful insights from the perspective of data-free model-agnostic knowledge distillation, and unreferenced text generation evaluation. Experiments and analysis on different NLP tasks, namely, text classification, question answering, and natural language inference, show the effectiveness of ZeroGen.

Open-ended text generation tasks, such as dialogue generation and story completion, require models to generate a coherent continuation given limited preceding context. The open-ended nature of these tasks brings new challenges to the neural auto-regressive text generators nowadays. Despite these neural models are good at producing human-like text, it is difficult for them to arrange causalities and relations between given facts and possible ensuing events. To bridge this gap, we propose a novel two-stage method which explicitly arranges the ensuing events in open-ended text generation. Our approach can be understood as a specially-trained coarse-to-fine algorithm, where an event transition planner provides a “coarse” plot skeleton and a text generator in the second stage refines the skeleton. Experiments on two open-ended text generation tasks demonstrate that our proposed method effectively improves the quality of the generated text, especially in coherence and diversity. We will release the codes to the community for further exploration.

A humanized dialogue system is expected to generate empathetic replies, which should be sensitive to the users’ expressed emotion. The task of empathetic dialogue generation is proposed to address this problem. The essential challenges lie in accurately capturing the nuances of human emotion and considering the potential of user feedback, which are overlooked by the majority of existing work. In response to this problem, we propose a multi-resolution adversarial model – EmpDG, to generate more empathetic responses. EmpDG exploits both the coarse-grained dialogue-level and fine-grained token-level emotions, the latter of which helps to better capture the nuances of user emotion. In addition, we introduce an interactive adversarial learning framework which exploits the user feedback, to identify whether the generated responses evoke emotion perceptivity in dialogues. Experimental results show that the proposed approach significantly outperforms the state-of-the-art baselines in both content quality and emotion perceptivity.