The joint multiple Intent Detection (ID) and Slot Filling (SF) is a significant challenge in spoken language understanding. Because the slots in an utterance may relate to multi-intents, most existing approaches focus on utilizing task-specific components to capture the relations between intents and slots. The customized networks restrict models from modeling commonalities between tasks and generalization for broader applications. To address the above issue, we propose a Unified Generative framework (UGEN) based on a prompt-based paradigm, and formulate the task as a question-answering problem. Specifically, we design 5-type templates as instructional prompts, and each template includes a question that acts as the driver to teach UGEN to grasp the paradigm, options that list the candidate intents or slots to reduce the answer search space, and the context denotes original utterance. Through the instructional prompts, UGEN is guided to understand intents, slots, and their implicit correlations. On two popular multi-intent benchmark datasets, experimental results demonstrate that UGEN achieves new SOTA performances on full-data and surpasses the baselines by a large margin on 5-shot (28.1%) and 10-shot (23%) scenarios, which verify that UGEN is robust and effective.