We present LangVAE, a novel framework for modular construction of variational autoencoders (VAEs) on top of pre-trained large language models (LLMs). Such language model VAEs can encode the knowledge of their pre-trained components into more compact and semantically disentangled representations. The representations obtained in this way can be analysed with the LangVAE companion framework: LangSpace, which implements a collection of probing methods, such as vector traversal and interpolation, disentanglement measures, and cluster visualisations. LangVAE and LangSpace offer a flexible, efficient and scalable way of building and analysing textual representations, with simple integration for models available on the HuggingFace Hub. Additionally, we conducted a set of experiments with different encoder and decoder combinations, as well as annotated inputs, revealing a wide range of interactions across architectural families and sizes w.r.t.generalisation and disentanglement. Our findings demonstrate a promising framework for systematising the experimentation and understanding of textual representations.

We present BioLunar, developed using the Lunar framework, as a tool for supporting biological analyses, with a particular emphasis on molecular-level evidence enrichment for biomarker discovery in oncology. The platform integrates Large Language Models (LLMs) to facilitate complex scientific reasoning across distributed evidence spaces, enhancing the capability for harmonizing and reasoning over heterogeneous data sources. Demonstrating its utility in cancer research, BioLunar leverages modular design, reusable data access and data analysis components, and a low-code user interface, enabling researchers of all programming levels to construct LLM-enabled scientific workflows. By facilitating automatic scientific discovery and inference from heterogeneous evidence, BioLunar exemplifies the potential of the integration between LLMs, specialised databases and biomedical tools to support expert-level knowledge synthesis and discovery.