Leveraging Knowledge Graph-Enhanced LLMs for Context-Aware Medical Consultation

Su-Hyeong Park, Ho-Beom Kim, Seong-Jin Park, Dinara Aliyeva, Kang-Min Kim


Abstract
Recent advancements in large language models have significantly influenced the field of online medical consultations. However, critical challenges remain, such as the generation of hallucinated information and the integration of up-to-date medical knowledge. To address these issues, we propose **I**nformatics **Llama** (ILlama), a novel framework that combines retrieval-augmented generation with a structured medical knowledge graph. ILlama incorporates relevant medical knowledge by transforming subgraphs from a structured medical knowledge graph into text for retrieval-augmented generation. By generating subgraphs from the medical knowledge graph in advance, specifically focusing on diseases and symptoms, ILlama is able to enhance the accuracy and relevance of its medical reasoning. This framework enables effective incorporation of causal relationships between symptoms and diseases. Also, it delivers context-aware consultations aligned with user queries. Experimental results on the two medical consultation datasets demonstrate that ILlama outperforms the strong baselines, achieving a semantic similarity F1-score of 0.884 when compared with ground truth consultation answers. Furthermore, qualitative analysis of ILlama’s responses reveals significant improvements in hallucination reduction and clinical usefulness. These results suggest that ILlama has strong potential as a reliable tool for real-world medical consultation environments.
Anthology ID:
2025.emnlp-main.1549
Volume:
Proceedings of the 2025 Conference on Empirical Methods in Natural Language Processing
Month:
November
Year:
2025
Address:
Suzhou, China
Editors:
Christos Christodoulopoulos, Tanmoy Chakraborty, Carolyn Rose, Violet Peng
Venue:
EMNLP
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
30447–30463
Language:
URL:
https://preview.aclanthology.org/author-page-yu-wang-polytechnic/2025.emnlp-main.1549/
DOI:
10.18653/v1/2025.emnlp-main.1549
Bibkey:
Cite (ACL):
Su-Hyeong Park, Ho-Beom Kim, Seong-Jin Park, Dinara Aliyeva, and Kang-Min Kim. 2025. Leveraging Knowledge Graph-Enhanced LLMs for Context-Aware Medical Consultation. In Proceedings of the 2025 Conference on Empirical Methods in Natural Language Processing, pages 30447–30463, Suzhou, China. Association for Computational Linguistics.
Cite (Informal):
Leveraging Knowledge Graph-Enhanced LLMs for Context-Aware Medical Consultation (Park et al., EMNLP 2025)
Copy Citation:
PDF:
https://preview.aclanthology.org/author-page-yu-wang-polytechnic/2025.emnlp-main.1549.pdf
Checklist:
 2025.emnlp-main.1549.checklist.pdf