Large Language Models (LLMs) have shown promising potential in the medical domain, assisting with tasks like clinical note generation and patient communication. However, current LLMs are limited to text-based communication, hindering their ability to interact with diverse forms of information in clinical environments. Despite clinical agents succeeding in diverse signal interaction, they are oriented to a single clinical scenario and hence fail for broader applications. To evaluate clinical agents holistically, we propose ClinicalAgent Bench (CAB), a comprehensive medical agent benchmark consisting of 18 tasks across five key realistic clinical dimensions. Building on this, we introduce ReflectTool, a novel framework that excels at utilizing domain-specific tools within two stages. The first optimization stage progressively enlarges a long-term memory by saving successful solving processes and tool-wise experience of agents in a tiny pre-defined training set. In the following inference stage, ReflectTool can search for supportive successful demonstrations from already built long-term memory to guide the tool selection strategy, and a verifier improves the tool usage according to the tool-wise experience with two verification methods–iterative refinement and candidate selection. Extensive experiments on CAB demonstrate that ReflectTool surpasses the pure LLMs with more than 10 points and the well-established agent-based methods with 3 points, highlighting its adaptability and effectiveness in solving complex clinical tasks. Our code and datasets are available at https://github.com/BlueZeros/ReflecTool.

Large language models hold promise for addressing medical challenges, such as medical diagnosis reasoning, research knowledge acquisition, clinical decision-making, and consumer health inquiry support. However, they often generate hallucinations due to limited medical knowledge. Incorporating external knowledge is therefore critical, which necessitates multi-source knowledge acquisition. We address this challenge by framing it as a source planning problem, which is to formulate context-appropriate queries tailored to the attributes of diverse sources. Existing approaches either overlook source planning or fail to achieve it effectively due to misalignment between the model’s expectation of the sources and their actual content. To bridge this gap, we present MedOmniKB, a repository comprising multigenre and multi-structured medical knowledge sources. Leveraging these sources, we propose the Source Planning Optimisation method, which enhances multi-source utilisation. Our approach involves enabling an expert model to explore and evaluate potential plans while training a smaller model to learn source alignment. Experimental results demonstrate that our method substantially improves multi-source planning performance, enabling the optimised small model to achieve state-of-the-art results in leveraging diverse medical knowledge sources.

Recently the retrieval-augmented generation (RAG) has been successfully applied in code generation. However, existing pipelines for retrieval-augmented code generation (RACG) employ static knowledge bases with a single source, limiting the adaptation capabilities of Large Language Models (LLMs) to domains they have insufficient knowledge of. In this work, we develop a novel pipeline, EVOR, that employs the synchronous evolution of both queries and diverse knowledge bases. On two realistic settings where the external knowledge is required to solve code generation tasks, we compile four new datasets associated with frequently updated libraries and long-tail programming languages, named EVOR-BENCH. Extensive experiments demonstrate that EVOR achieves two to four times of execution accuracy compared to other methods such as Reflexion (Shinn et al., 2024), DocPrompting (Zhou et al., 2023), etc. We demonstrate that EVOR is flexible and can be easily combined with them to achieve further improvement. Further analysis reveals that EVOR benefits from the synchronous evolution of queries and documents and the diverse information sources in the knowledge base. We hope that our studies will inspire more insights into the design of advanced RACG pipelines in future research.

Large language models (LLMs) have shown substantial progress in natural language understanding and generation, proving valuable especially in the medical field. Despite advancements, challenges persist due to the complexity and diversity inherent in medical tasks, which can be categorized as knowledge-intensive tasks and alignment-required tasks. Previous approaches either ignore the latter task or focus on a minority of tasks and hence lose generalization. To address these drawbacks, we propose a progressive fine-tuning pipeline. This pipeline employs a and a to encode diverse knowledge in the first stage and filter out detrimental information. In the second stage, we drop the to avoid the interference of suboptimal representation and leverage an additional alignment module optimized towards an orthogonal direction to the knowledge space to mitigate knowledge forgetting. Based on this two-stage paradigm, we proposed a Medical LLM through decoupling Clinical Alignment and Knowledge Aggregation (), which is designed to achieve promising performance on over 20 medical tasks, as well as results on specific medical alignment tasks. Various model sizes of (1.8B, 7B, 14B) all demonstrate significant improvements over existing models with similar model sizes. Our code and datasets are available at https://github.com/BlueZeros/MedCare.

Although Non-autoregressive Transformer (NAT) models have achieved great success in terms of fast inference speed, this speedup comes with a performance drop due to the inherent multi-modality problem of the NAT model. Previous works commonly alleviate this problem by replacing the target side of the raw data with distilled data generated by Autoregressive Transformer (AT) models. However, the multi-modality problem in the distilled data is still significant and thus limits further improvement of the NAT models. In this paper, we propose a method called Sequence-Level Self-Distillation (SLSD), which aims to generate distilled data by the NAT model itself, eliminating the need for additional teacher networks. Furthermore, SLSD can adapt to different NAT models without precise adjustments since the self-distilled data is generated from the same types of NAT models. We conduct extensive experiments on WMT14 EN↔DE and WMT16 EN↔RO and choose four classic NAT models as the backbones to validate the generality and effectiveness of SLSD. The results show that our approach can consistently improve all models on both raw data and distilled data without sacrificing the inference speed.