SubmissionNumber#=%=#30 FinalPaperTitle#=%=#Gender-Neutral Large Language Models for Medical Applications: Reducing Bias in PubMed Abstracts ShortPaperTitle#=%=# NumberOfPages#=%=#10 CopyrightSigned#=%=#Elizabeth Schaefer JobTitle#==# Organization#==#Yale University, Department of Computer Science, 51 Prospect St, New Haven, CT 06511 Abstract#==#This paper presents a pipeline for mitigating gender bias in large language models (LLMs) used in medical literature by neutralizing gendered occupational pronouns. A set of 379,000 PubMed abstracts from 1965-1980 was processed to identify and modify pronouns tied to professions. We developed a BERT-based model, "Modern Occupational Bias Elimination with Refined Training," or "MOBERT," trained on these neutralized abstracts, and compared it with "1965BERT," trained on the original dataset. MOBERT achieved a 70% inclusive replacement rate, while 1965BERT reached only 4%. A further analysis of MOBERT revealed that pronoun replacement accuracy correlated with the frequency of occupational terms in the training data. We propose expanding the dataset and refining the pipeline to improve performance and ensure more equitable language modeling in medical applications. Author{1}{Firstname}#=%=#Elizabeth Author{1}{Lastname}#=%=#Schaefer Author{1}{Username}#=%=#eschaefer17 Author{1}{Email}#=%=#schaefer.elizabeth@gmail.com Author{1}{Affiliation}#=%=#Yale University Author{2}{Firstname}#=%=#Kirk Author{2}{Lastname}#=%=#Roberts Author{2}{Username}#=%=#captkrob Author{2}{Email}#=%=#kirkroberts@gmail.com Author{2}{Affiliation}#=%=#University of Texas Health Science Center at Houston ========== èéáğö