@inproceedings{yoo-etal-2025-enhancing,
    title = "Enhancing Antimicrobial Drug Resistance Classification by Integrating Sequence-Based and Text-Based Representations",
    author = "Yoo, Hyunwoo  and
      Sokhansanj, Bahrad  and
      Brown, James",
    editor = "Demner-Fushman, Dina  and
      Ananiadou, Sophia  and
      Miwa, Makoto  and
      Tsujii, Junichi",
    booktitle = "ACL 2025",
    month = aug,
    year = "2025",
    address = "Viena, Austria",
    publisher = "Association for Computational Linguistics",
    url = "https://preview.aclanthology.org/acl25-workshop-ingestion/2025.bionlp-1.23/",
    pages = "263--273",
    ISBN = "979-8-89176-275-6",
    abstract = "Antibiotic resistance identification is essential for public health, medical treatment, and drug development. Traditional sequence-based models struggle with accurate resistance prediction due to the lack of biological context. To address this, we propose an NLP-based model that integrates genetic sequences with structured textual annotations, including gene family classifications and resistance mechanisms. Our approach leverages pretrained language models for both genetic sequences and biomedical text, aligning biological metadata with sequence-based embeddings. We construct a novel dataset based on the Antibiotic Resistance Ontology (ARO), consolidating gene sequences with resistance-related textual information. Experiments show that incorporating domain knowledge significantly improves classification accuracy over sequence-only models, reducing reliance on exhaustive laboratory testing. By integrating genetic sequence processing with biomedical text understanding, our approach provides a scalable and interpretable solution for antibiotic resistance prediction."
}