As Large Language Models (LLMs) increasingly influence content generation across diverse platforms, there is a heightened urgency to regulate their outputs to ensure safe usage. However, defining safety is complex, given that entities across domains may interpret it through varied lenses and develop safety detectors—models trained to identify specific unsafe content based on predefined criteria. To address this complexity, we introduce the approach of Adaptive Integration of Detectors (AID) to orchestrate the strengths of multiple pretrained detectors to ensure comprehensive effectiveness in diverse scenarios. AID employs a Mixture-of-Experts (MoE) framework, wherein it dynamically assigns and learns data-adaptive weights for each detector using domain-specific annotated data and LLM-extracted features. We provide theoretical insights into why MoE can be effective by showing its optimality in a Neyman-Pearson setting. Our experimental studies using various detection tasks curated from benchmark datasets demonstrate AID’s ability to synergistically combine the unique capabilities of individual detectors. For example, it is observed that AID can improve the area under the curve (AUC) by an absolute value of 0.07 to 0.21, with a median of 0.12, compared to the best individual detectors developed for specific safety aspects. The improvement is particularly significant for complex detection tasks that mix different unsafe data sources.